| dactinomycin | <chemical> An antitumour antibiotic derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. Pharmacological action: antibiotics, antineoplastic, antibiotics, peptide, nucleic acid synthesis inhibitors, protein synthesis inhibitor. Chemical name: Actinomycin D (12 Dec 1998) |
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