DID : KMLE 의학 검색 엔진 - 의학사전, 의학용어, 의학약어, 의학논문, 약품/의약품 검색

MeSH(Medical Subject Headings) 맞춤 검색 (http://www.nlm.nih.gov) 결과 : 4 페이지: 1

Didanosine - 새창 A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Synonyms : Bristol-Myers Brand of Didanosine, Bristol-Myers Squibb Brand of Didanosine, NSC-612049, Videx, 2', 3' Dideoxyinosine, Bristol Myers Brand of Didanosine, Bristol Myers Squibb Brand of Didanosine, NSC 612049, NSC612049
Didelphis - 새창 A genus of large OPOSSUMS in the family Didelphidae, found in the Americas. The species Didelphis virginiana is prominent in North America.
Synonyms : Didelphis virginiana, North American Opossum, North American Opossums, Opossums, North American
Dideoxyadenosine - 새창 A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
Synonyms : 2', 3' Dideoxyadenosine
Dideoxynucleosides - 새창 Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
Synonyms : ddNus, 2', 3' Dideoxynucleosides