Cytochrome P-450 Enzyme System : KMLE 의학 검색 엔진 - 의학사전, 의학용어, 의학약어, 의학논문, 약품/의약품 검색

MeSH(Medical Subject Headings) 맞춤 검색 (http://www.nlm.nih.gov) 결과 : 1 페이지: 1

Cytochrome P-450 Enzyme System - 새창 A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Synonyms : Cytochrome P-450 Monooxygenase, Cytochrome P-450 Oxygenase, Cytochrome P450, Cytochrome P 450, Cytochrome P 450 Dependent Monooxygenase, Cytochrome P 450 Enzyme System, Cytochrome P 450 Monooxygenase, Cytochrome P 450 Oxygenase, Monooxygenase, Cytochrome P-450