| Clostridium histolyticum collagenase | <enzyme> An enzyme that catalyses the hydrolysis of collagen, preferentially at peptide bonds on the amino side of a glycylprolyl sequence. Synonym: clostridiopeptidase A, collagenase A, collagenase I. (05 Mar 2000) |
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| Clostridium histolyticum | A species found in war wounds, where it induces necrosis of tissue; it produces a cytolytic exotoxin that causes local necrosis and sloughing on injection; it is not toxic on feeding; it is pathogenic for small laboratory animals. (05 Mar 2000) |
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| Clostridium histolyticum proteinase B | A cysteine proteinase cleaving preferentially at the carboxyl side of arginyl and lysyl residues. It also has an esterase activity. Synonym: clostridiopeptidase B, Clostridium histolyticum proteinase B. (05 Mar 2000) |
| microbial collagenase | <enzyme> A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -gly in the sequence -pro-xaa-gly-pro-. Six forms (or 2 classes) have been isolated from clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from bacillus cereus, empedobacter collagenolyticum, pseudomonas marinoglutinosa, and species of vibrio and streptomyces. Registry number: EC 3.4.24.3 (12 Dec 1998) |
| collagenase | <enzyme> Proteolytic enzyme capable of breaking native collagen. Once the initial cleavage is made, less specific proteases will complete the degradation. Collagenases from mammalian cells are metallo enzymes and are collagen type specific. May be released in latent (proenzyme) form into tissues and require activation by other proteases before they will degrade fibrillar matrix. Bacterial collagenases are used in tissue disruption for cell harvesting. (18 Nov 1997) |
| collagenase A | <enzyme> An enzyme that catalyses the hydrolysis of collagen, preferentially at peptide bonds on the amino side of a glycylprolyl sequence. Synonym: clostridiopeptidase A, collagenase A, collagenase I. (05 Mar 2000) |
| neutrophil collagenase | <enzyme> Cleaves interstitial collagens in the triple helical domain; cleaves type I collagen more rapidly than type III; fibroblast collagenase cleaves at the same site as neutrophil colagenase Registry number: EC 3.4.24.34 Synonym: matrix metalloproteinase 8, mmp-8, mmp 8, fibroblast collagenase (26 Jun 1999) |
| Clostridium | <bacteria> Genus of gram-positive anaerobic spore forming bacilli commonly found in soil. Many species produce exotoxins of great potency, the best known being clostridium botulinum and clostridium tetani. (15 Jan 1998) |
| Clostridium bifermentans | A species found in putrid meat and gaseous gangrene; also commonly found in soil, faeces, and sewage. Its pathogenicity varies from strain to strain. (05 Mar 2000) |
| clostridium botulinum | The aetiologic agent of botulism in man, wild ducks, and other waterfowl. It is also responsible for certain forms of forage poisoning in horses and cattle. The bacterium produces a powerful exotoxin that is resistant to proteolytic digestion. (12 Dec 1998) |
| Clostridium butyricum | A species which occurs in naturally soured milk, in naturally fermented starchy plant substances, and in soil; it is not pathogenic. It is the type species of the genus Clostridium. (05 Mar 2000) |
| Clostridium cadaveris | A species found in a human cadaver and in the peritoneum of a rabbit; it is not pathogenic for guinea pigs or rabbits. (05 Mar 2000) |
| Clostridium carnis | A species found in a rabbit inoculated with soil; it is pathogenic for laboratory animals, in which an exotoxin produces oedema, necrosis, and death. (05 Mar 2000) |
| Clostridium chauvoei | A species which causes blackleg, black quarter, or symptomatic anthrax in cattle and other animals and which produces an exotoxin. (05 Mar 2000) |
| Clostridium cochlearium | A species found in human war wounds and septic infections; it is not pathogenic for guinea pigs. (05 Mar 2000) |
| Clostridium colinum | A species causing ulcerative enteritis in quail and chickens. (05 Mar 2000) |