| ciliary neurotrophic factor | <growth factor> Neurotrophic factor originally characterised as a survival factor for chick ciliary neurons in vitro. Subsequently shown to promote the survival of a variety of other neuronal cell types and to promote the differentiation of bipotential O2A progenitor cells to type 2 astrocytes in vitro. Molecular cloning and expression studies indicate that CNTF is a cytosolic protein. Developmental expression and regional distribution studies show that, unlike NGF, CNTF is not a target derived neurotrophic factor. (18 Nov 1997) |
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| brain-derived neurotrophic factor | <growth factor> Small basic protein purified from pig brain, a member of the family of neurotrophic factors that also includes Nerve Growth Factor and neurotrophin 3. In contrast to nerve growth factor, brain-derived neurotrophic factor is predominanantly (though not exclusively) localised in the CNS. It supports the survival of primary sensory neurons originating from the neural crest and ectodermal placodes that are not responsive to NGF. In the brain brain-derived neurotrophic factor has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. Acronym: BDGF (12 Dec 1998) |
| neurotrophic factor | A molecule, usually a protein, that will facilitate the growth or repair of nerve cells. (14 Nov 1997) |
| glycoprotein hormones, alpha subunit | A non-covalently bound subunit of the glycoprotein hormones tsh, fsh, lh, and hcg which originates in the anterior pituitary gland and placenta. This subunit is virtually identical in structure and indistinguishable by radioimmunoassay in all of the above glycoproteins. It is present in both men and women, but is elevated in postmenopausal women and in patients with hypothyroidism, uraemia and malignant tumours. The alpha subunit may be involved directly in recognition of certain receptors. (12 Dec 1998) |
| phycocyanin alpha-subunit phycocyanobilin lyase | <enzyme> Cleaves thioether bond attaching phycocyanobilin to the alpha subunit of phycocyanin; product of the cpce and cpcf genes of synechococcus Registry number: EC 4.4.- Synonym: phycocyanobilin lyase (26 Jun 1999) |
| phycoerythrocyanin alpha-subunit phycobiliviolin lyase | <enzyme> Shows high degree of homology to phycocyanobilin lyase Registry number: EC 4.4.- Synonym: phycobiliviolin lyase, pece protein, pecf protein, pec alpha-subunit phycobiliviolin lyase (26 Jun 1999) |
| neurotrophic | Involved in the nutrition (or maintenance) of neural tissue. Classic example is nerve growth factor. (18 Nov 1997) |
| neurotrophic atrophy | Abnormalities of the skin, hair, nails, subcutaneous tissues and bone, caused by peripheral nerve lesions. Synonym: neuritic atrophy, neurogenic atrophy, neurotrophic atrophy, trophic changes. (05 Mar 2000) |
| neurotrophic keratitis | Inflammation of the cornea after corneal anaesthesia. Synonym: neuroparalytic keratitis. (05 Mar 2000) |
| gene rearrangement, alpha-chain T-cell antigen receptor | Ordered rearrangement of T-cell variable gene regions coding for the alpha-chain of antigen receptors. (12 Dec 1998) |
| genes, T-cell receptor alpha | DNA sequences encoding the alpha chain of the T-cell receptor. The genomic organization of the tcr alpha genes is essentially the same in all species and is similar to the organization of ig genes. (12 Dec 1998) |
| gamma subunit, cGMP phosphodiesterase | <enzyme> Isolated from canine retinal rod photoreceptor cells; genbank u49359 Registry number: EC 3.1.14.- Synonym: pde-gamma, pdegamma, cgmp-pde gamma subunit (26 Jun 1999) |
| ribulose-1,5-bisphosphate carboxylase-oxygenase large subunit epsilonN-methyltransferase | <enzyme> An aspect of EC 2.1.1.43; trimethylates lys-14 of rubisco Registry number: EC 2.1.1.- Synonym: rubisco lsmt, rubisco large subunit lysine n-methyltransferase (26 Jun 1999) |
| cholera toxin, B subunit-horseradish peroxidase | <chemical> Conjugate of horseradish peroxidase and cholera toxin Synonym: bhrp, horseradish peroxidase-cholera toxin b subunit, cholera toxin-horseradish peroxidase, horseradish peroxidase-cholera toxin, ib4-hrp (26 Jun 1999) |
| chorionic gonadotropin, beta subunit, human | The beta subunit of human chorionic gonadotropin. It is used as a clinical marker to facilitate early detection of normal pregnancy and significantly contributes to the diagnosis of various pregnancy-related disorders, such as ectopic pregnancy, spontaneous abortion, hydatidiform mole, choriocarcinoma, or trisomy 21. Further, determination of this marker is immensely helpful to guide curative intervention in testicular cancer. Other possible clinical uses includes as a marker of cancers of the bladder, pancreas, or biliary tract. (scan j clin lab invest suppl 1993;216:97-104) (12 Dec 1998) |