| charcot-marie disease | A hereditary motor and sensory neuropathy transmitted as an autosomal dominant trait and characterised by progressive distal wasting and loss of reflexes in the muscles of the legs (occasionally of the arms). Onset is usually in the second to fourth decades. (12 Dec 1998) |
|---|---|
| Charcot-Marie-Tooth disease | <disease> A slowly progressive genetic disorder which is the most common of the inherited peripheral neuropathies, and encompasses a family of disorders characterised by distal muscle weakness and diminished nerve conduction velocity, due to the destruction of nerves with degeneration of the myelin sheath. Features include muscle atrophy in the feet and the legs, progressing to the hands and arms, often with foot drop and a slapping gait. The predominant variety, designated CMT1, is an autosomal dominant disorder caused, in most cases, by duplication of a very large (1.5 Mb) region on chromosome 17p11.2-12. A related condition, hereditary neuropathy with liability to pressure palsies (HNPP), is associated with a large deletion in the same general region. There is no specific treatment for this disorder. (16 Dec 1997) |
| Charcot's disease | A serious neurologic disease that results from the progressive degeneration of the motor neurons. (27 Sep 1997) |
| Erb-Charcot disease | A type of cerebral palsy in which there is bilateral spasticity, with the lower extremities more severely affected. Compare: flaccid paralysis. Synonym: Erb-Charcot disease, infantile diplegia, Little's disease, spastic spinal paralysis, tabes spasmodica. (05 Mar 2000) |
| Charcot-Bottcher crystalloids | Spindle-shaped crystalloid's 10 to 25 um long, found in human Sertoli cells. (05 Mar 2000) |
| Charcot-Bouchard aneurysm | Dilatation in the diameter of small arteries and arterioles secondary to lipohyalinosis from long-standing hypertension associated with intracerebral haematomas. Synonym: Charcot-Bouchard aneurysm. (05 Mar 2000) |
| Charcot, Jean | <person> French neurologist, 1825-1893. See: Charcot's arteries, Charcot's disease, Charcot's intermittent fever, Charcot's gait, Charcot's joint, Charcot's syndrome, Charcot's triad, Charcot's vertigo, Charcot-Leyden crystals, Charcot-Neumann crystals, Charcot-Robin crystals, Charcot-Bottcher crystalloids, Charcot-Marie-Tooth disease, Charcot-Weiss-Baker syndrome, Erb-Charcot disease. (05 Mar 2000) |
| Charcot-Leyden crystals | Crystal's in the shape of elongated double pyramids, formed from eosinophils, found in the sputum in bronchial asthma and in other exudates or transudates containing eosinophils. Synonym: asthma crystals, Charcot-Neumann crystals, Charcot-Robin crystals, Leyden's crystals. (05 Mar 2000) |
| Charcot-Neumann crystals | Crystal's in the shape of elongated double pyramids, formed from eosinophils, found in the sputum in bronchial asthma and in other exudates or transudates containing eosinophils. Synonym: asthma crystals, Charcot-Neumann crystals, Charcot-Robin crystals, Leyden's crystals. (05 Mar 2000) |
| Charcot-Robin crystals | Crystal's in the shape of elongated double pyramids, formed from eosinophils, found in the sputum in bronchial asthma and in other exudates or transudates containing eosinophils. Synonym: asthma crystals, Charcot-Neumann crystals, Charcot-Robin crystals, Leyden's crystals. (05 Mar 2000) |
| Charcot's arteries | Any one of a variety of small artery's entering the base of the brain through the anterior perforated substance and supplying the striatum, globus pallidus, and internal capsule; most of these perforating arteries are branches of the M1 segment (clinical terminology) of the middle cerebral and and (rarely) of the anterior choroidal artery. Synonym: Charcot's arteries, lateral striate arteries. (05 Mar 2000) |
| charcot's foot | A foot disease associated with diabetic neuropathy that results in destruction of joints and soft tissue. (09 Oct 1997) |
| Charcot's gait | The gait of hereditary ataxia. (05 Mar 2000) |
| Charcot's intermittent fever | Fever, chills, right upper quadrant pain, and jaundice associated with intermittently obstructing common duct stones. (05 Mar 2000) |
| charcot's joint | A joint that is deprived of any pain or position sense due to severe osteoarthritis. May also occur as the result of tabes dorsalis, diabetic neuropathy, amyloidosis or leprosy. Often treated with surgical fusion. (27 Sep 1997) |