| antibodies, catalytic | Antibodies that can catalyze a wide variety of chemical reactions. They are characterised by high substrate specificity and share many mechanistic features with enzymes. (12 Dec 1998) |
|---|---|
| catalytic | Relating to or effecting catalysis. (05 Mar 2000) |
| catalytic antibody | <chemistry> Antibody raised against a transition state analogue (e.g. A phosphate analogue of a carboxylic acid ester transition state) that can then catalyse the analogous chemical reaction, though not as effectively as a true enzyme. (16 Mar 1998) |
| catalytic centre | See: active centre. (05 Mar 2000) |
| catalytic model | <epidemiology> A (rather misleading name for a) type of compartmental model in which the force of infection is treated as a parameter to be estimated. (05 Dec 1998) |
| catalytic site | <chemistry> The site on an enzyme where the substrate or substrates (the reactants of a chemical or biochemical reaction) attach in order to convert to the product or products of the reaction, at a much higher speed than the substrate would need to convert to the product alone. (16 Mar 1998) |
| RNA, catalytic | RNA which contains an intron sequence that has an enzyme-like catalytic activity. This intron sequence has been shown to fold up to form a complex surface that can function like an enzyme in reactions with other RNA molecules and thus synthesise new molecules even in the absence of protein. (12 Dec 1998) |
| apple domain | <molecular biology> A consensus sequence, composed of 90 amino acids including 6 cysteines, that forms a characteristic, vaguely apple shaped, pattern via disulphide bridges. Shared by plasma kallikrein and coagulation factor XI, both serine proteases. (18 Nov 1997) |
| carboxy-terminal domain kinase | <enzyme> Protein kinase that phosphorylates the c-terminal repeat domain of the largest subunit of RNA polymerase II at serine residues Registry number: EC 2.7.1.- Synonym: ctd kinase, hs-ctd kinase, tfiih-associated ctd kinase (26 Jun 1999) |
| paired box domain | <molecular biology> Conserved domain of 128 amino acids, found in several developmentally regulated proteins in Drosophila (for example paired, gooseberry, Pox), mouse and human (for example Pax, HuP1, HuP48). (18 Nov 1997) |
| POU domain | <molecular biology> A conserved protein domain of around 150 amino acids, composed of a 20 amino acid homeobox domain and a larger POU specific domain and so is the target of some transcription factors. Named POU (Pit Oct Unc) after 3 such proteins: Pit 1 regulates expression of certain pituitary genes, Oct 1 and 2, that bind an octamer sequence in the promoters of histone H2A and some immunoglobulin genes and Unc 86, involved in nematode sensory neuron development. (31 Dec 1997) |
| SH3 domain-containing proline-rich kinase | <enzyme> A protein kinase which both phosphorylates ser and thr residues and has an sh3 domain; contains 847 amino acid residues; mol mass 92,688 da; genbank u07747 Registry number: EC 2.7.10.- Synonym: src-homology 3 domain-containing proline-rich kinase, sprk protein, sprk gene product (26 Jun 1999) |
| dinucleotide domain | A structural domain in certain proteins that binds NAD+ or NADP+. Synonym: dinucleotide domain. (05 Mar 2000) |
| domain | <molecular biology> Used to describe a part of a molecule or structure that shares common physico chemical features, for example hydrophobic, polar, globular, helical domains or properties for example DNA binding domain, ATP binding domain. (18 Nov 1997) |
| EGF like domain | Region of 30-40 amino acids containing 6 cysteines found originally in EGF and also in a range of proteins involved in cell signalling. Examples: TGF _, amphiregulin, urokinase, tissue plasminogen activator, complement C6 C9, fibronectin, laminin (each subunit at least 13 times), nidogen, selectins. It is also found in the Drosophila gene products: Notch (36 times) Delta, Slit, Crumbs, Serrate. (18 Nov 1997) |