| COS cell | <cell culture> A cell line derived from the african green monkey and used for transfection and cloning. The cells are simian fibroblasts (CV 1 cells) transformed by SV40 that is deficient in the origin of replication region. They express large T antigen constitutively and if transfected with a vector containing a normal SV40 origin have all the other early viral genes necessary to generate multiple copies of the vector and thus to give very high levels of expression. (04 Jul 1999) |
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| cos site | <molecular biology> A 12-nucleotide bases-long segment of single stranded DNA that exists at both ends of the bacteriophage lambda's double-stranded genome. The two cos sites at the ends of the genome are complementary to one another so that the genome can become circular once the virus has infected a host bacterium. The circular genome can then be duplicated continuously until there are many repeats of it strung together, the cos sites show the virus where to cut them apart right before they are packaged into individual capsids as new progeny viruses ready to infect more host cells. (10 Nov 1998) |
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| Hippocrates of Cos | Greek physician, called the "Father of Medicine," circa 460-377 B.C. See: hippocratic facies, hippocratic fingers, hippocratic nails, school, succussion. (05 Mar 2000) |
| T-cell-rich, B-cell lymphoma | <tumour> A B-cell lymphoma in which more than 90% of the cells are of T-cell origin, masking the large cells that form the neoplastic B-cell component. See: adult T-cell lymphoma. (05 Mar 2000) |
| absorption cell | A small glass chamber with parallel sides, in which absorption spectra of solutions can be obtained. (05 Mar 2000) |
| acid cell | One of the cell's of the gastric glands; it lies upon the basement membrane, covered by the chief cell's, and secretes hydrochloric acid that reaches the lumen of the gland through fine intracellular and intercellular canals (canaliculi). Synonym: acid cell, oxyntic cell. (05 Mar 2000) |
| acidophil cell | A cell whose cytoplasm or its granules stain with acid dyes. (05 Mar 2000) |
| acinar cell | Any secreting cell lining an acinus, especially applied to the cell's of the pancreas that furnish pancreatic juice and enzymes to distinguish them from the cell's of ducts and the islets of Langerhans. Synonym: acinous cell. (05 Mar 2000) |
| acinar cell tumour | A solid and cystic tumour of the pancreas, occurring in young women; tumour cells contain zymogen granules. (05 Mar 2000) |
| acinic cell adenocarcinoma | <tumour> An adenocarcinoma arising from secreting cells of a racemose gland, particularly the salivary glands. Synonym: acinar carcinoma, acinic cell carcinoma, acinose carcinoma, acinous carcinoma. (05 Mar 2000) |
| acinic cell carcinoma | <tumour> An adenocarcinoma arising from secreting cells of a racemose gland, particularly the salivary glands. Synonym: acinar carcinoma, acinic cell carcinoma, acinose carcinoma, acinous carcinoma. (05 Mar 2000) |
| acinous cell | Any secreting cell lining an acinus, especially applied to the cell's of the pancreas that furnish pancreatic juice and enzymes to distinguish them from the cell's of ducts and the islets of Langerhans. Synonym: acinous cell. (05 Mar 2000) |
| acoustic cell | A hair cell of the organ of Corti. (05 Mar 2000) |
| adenocarcinoma, clear cell | An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumour cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumours, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (12 Dec 1998) |
| adenoid squamous cell carcinoma | <tumour> A malignant neoplasm consisting chiefly of glandular epithelium (adenocarcinoma), usually well differentiated, with foci of metaplasia to squamous (or epidermoid) neoplastic cells. Synonym: adenoid squamous cell carcinoma. (05 Mar 2000) |
| adenoma, islet cell | A benign tumour of the islets of langerhans that may occur anywhere throughout the pancreas. Such tumours may result in hyperinsulinism or zollinger-ellison syndrome. (12 Dec 1998) |