| COOH-terminal signal transamidase | <enzyme> Present in the endoplasmic reticulum; catalyses concomitant cleavage of the signal peptide of nascent proteins destined to be processed to a glycosylphosphatidylinositol (gpi) and addition of the gpi anchor Registry number: EC 2.3.2.- Synonym: cooh-ts-transamidase, gpi transamidase, gpti transamidase (26 Jun 1999) |
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| cooing murmur | A murmur, usually of mitral regurgitation, of very high pitch resembling the cooing of a pigeon or a dove. (05 Mar 2000) |
| Cooke's speculum | A three-pronged speculum for rectal examinations and operations. (05 Mar 2000) |
| Cooke, A Bennett | <person> U.S. Physician, *1869. See: Cooke's speculum. (05 Mar 2000) |
| cookery | The art or practice of cooking. It includes the preparation of special foods for diets in various diseases. (12 Dec 1998) |
| coolant | <radiobiology> Substance circulated through a device (including fusion reactors, fusion reactor magnets, etc.) to remove or transfer heat. Types commonly considered for fusion reactors include water, helium, and liquid metals such as sodium (Na). (09 Oct 1997) |
| cooled-knife method | The cutting of frozen sections with a knife cooled to a few degrees below the freezing point. (05 Mar 2000) |
| Cooley's anaemia | <haematology> A genetic disease that results when there is a defect in the synthesis of one (or more) of the subunits of haemoglobin. The subunits are referred to as alpha or beta globin chains. As a result of a genetic defect red blood cells are small and hypochromic (low haemoglobin in the cell). Anaemia is common. Incidence is approximately 4 out of 100,000 individuals. Genetic testing is recommended in pregnant females of Mediterranean descent for the purpose of identifying carriers of this potentially serious genetic disease. Origin: Gr. Haima = blood (27 Sep 1997) |
| Cooley, Thomas | <person> U.S. Paediatrician, 1871-1945. See: Cooley's anaemia. (05 Mar 2000) |
| Coolidge tube | An X-ray tube, in which the cathode consists of a tungsten wire spiral surrounded by a focusing cup; the tungsten spiral is heated by an electric current; the quantity and quality of the X-rays so generated are regulated by varying the temperature of the cathode and the voltage between cathode and anode. (05 Mar 2000) |
| Coolidge, William | <person> U.S. Physicist, 1873-1974. See: Coolidge tube. (05 Mar 2000) |
| coolie itch | Cutaneous larva migrans caused by larvae of hookworms. Synonym: ancylostoma dermatitis, ancylostomiasis cutis, coolie itch, dew itch, ground itch, swamp itch, swimmer's itch, toe itch, water itch, water sore. (05 Mar 2000) |
| Coomassie blue | Stain commonly used non-specifically for proteins on gels. Recently renamed Kenacid Blue. (18 Nov 1997) |
| Coomassie brilliant blue R-250 | A general protein stain used in electrophoresis because of its unusual sensitivity. Origin: originally, a proprietary name of Imperial Chemical; Coomassie (Kumasi), Ghana (05 Mar 2000) |
| Coombs murmur | A blubbering apical middiastolic murmur occurring in the acute stage of rheumatic mitral valvulitis and disappearing as the valvulitis subsides. Synonym: Coombs murmur. (05 Mar 2000) |