| BrDu | <chemical> A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumours. Pharmacological action: antimetabolites, antimetabolites, antineoplastic, antiviral agents, radiation-sensitizing agents. Chemical name: Uridine, 5-bromo-2'-deoxy- (12 Dec 1998) |
|---|---|
| BrDu-banding | The labeling of chromosomes in proliferating tissue by adding an excess of bromodeoxyuridine, which replaces the uridine incorporated in RNA and fluoresces in ultraviolet light; the bands result from sister chromatid exchanges. (05 Mar 2000) |