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tablets Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form.
(12 Dec 1998)
tablets, enteric-coated Tablets coated with material that delays release of the medication until after they leave the stomach.
(12 Dec 1998)
atropine <drug> A toxic alkaloid extracted from belladonna and other members of thenightshade family, it is typically used to dilate the eye and to stopmuscular spasms.
Pharmacologic action: Parasympatholytic. Competitive blockade of acetylcholine at muscarinic receptors. Increases sinus node automaticity and AV conduction.
Uses: Treat bradycardia, asystole, and AV block
Dose: 0.5 - 1.0 mg for bradycardia every 3 - 5 min to a total dose of 0.04 mg/kg. Doses smaller than 0.5 mg can cause a paradoxical bradycardia due to sympathomimetic effects Typically 3 mg is adequate to completely block vagal effects Atropine is well absorbed via endotracheal route - administer 1-2 mg diluted in 10 mL sterile water or normal saline.
Potential complications: 1. Tachyarrhythmias 2. Exacerbation of myocardial ischemia 3. Low dose may cause paradoxical bradycardia 4. Dry mouth, urinary retention, flushed and hot skin 5. Crosses blood-brain barrier which can cause delirium
Note: The denervated heart will not respond to atropine.
(15 Mar 2000)
atropine dehydrase <enzyme> Proposed mechanism for conversion of atropine or scopolamine to apoatropine or aposcopolamine via a mechanism using hydroxysteroid sulfotransferase by guinea pig liver
Registry number: EC 2.8.2.-
Synonym: scopolamine dehydrase
(26 Jun 1999)
atropine derivatives Analogs and derivatives of atropine.
(12 Dec 1998)
atropine methonitrate The methylnitrate of atropine, with the same actions and uses as atropine, but less lipid-soluble and hence with fewer central nervous system effects; a quaternary compound.
(05 Mar 2000)
atropine methylbromide A quaternary derivative of atropine that is less lipid soluble and hence produces fewer central nervous system actions; a cycloplegic.
Synonym: atropine methylbromide.
(05 Mar 2000)
atropine sulfate An anticholinergic; a widely used soluble salt of atropine.
(05 Mar 2000)
atropine test If an injection of atropine relieves bradycardia, the condition is due to action of the vagus; if it does not, the condition may be due to an affection of the heart itself.
Synonym: atropine test.
(05 Mar 2000)
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