| asparaginase | <drug, enzyme> An enzyme that hydrolyses L asparagine to L aspartate and ammonia that is used as an antitumour agent especially against lymphosarcoma and lymphatic leukaemia. (18 Nov 1997) |
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| palmitoyl-L-asparaginase | <enzyme> Derivative of asparaginase which is incorporated into liposomes to avoid acute allergic reactions Pharmacological action: antineoplastic agent Registry number: EC 3.5.1.- Synonym: pal-asnase (26 Jun 1999) |
| monomethoxypolyethylene glycol-conjugated asparaginase | <chemical> Used in patients with haematological malignancies Synonym: peg(2)-asp, 2,4-bis(2-methoxypolyethyleneglycol)-6-chloro-s-triazine-conjugated l-asparaginase (26 Jun 1999) |
| PM-asparaginase | <enzyme> Asparaginase modified with a poly(ethylene glycol)-maleic anhydride copolymer; enzyme remains catalytically active but lacks immunoreactivity Pharmacological action: antineoplastic agent Registry number: EC 3.5.1.- Synonym: poly(ethylene glycol-co-maleic anhydride)-asparaginase (26 Jun 1999) |
| polyethyleneglycol-asparaginase | <chemical> Covalent attachment of peg to enzyme produces active, stable complex; non-immunogenic; used in treatment of leukaemia Pharmacological action: antineoplastic agent Synonym: peg-asparaginase, pegaspargase, oncaspar (26 Jun 1999) |
| polyethylene glycol-glutaminase-asparaginase | <chemical> Covalent attachment of polyethylene glycol to nonessential amine groups of enzyme renders it nonimmunogenic for treatment of leukaemia (EC 3.5.1.-) Pharmacological action: immunosuppressive agent Chemical name: glutaminase-asparaginase Synonym: polyethyleneglycol-l-glutaminase-l-asparaginase, peg-l-glutaminase-l-asparaginase (26 Jun 1999) |
| succinylated glutaminase-asparaginase | <enzyme> From acinetobacter glutaminasificans Pharmacological action: antineoplastic agent Registry number: EC 3.5.1.- Synonym: su-gln-asp (26 Jun 1999) |