| united states agency for health care policy and research | An agency of the public health service established in 1990 to "provide indexing, abstracting, translating, publishing, and other services leading to a more effective and timely dissemination of information on research, demonstration projects, and evaluations with respect to health care to public and private entities and individuals engaged in the improvement of health care delivery.." it supersedes the national centre for health services research. (12 Dec 1998) |
|---|---|
| growth and embryonic development | Developmental processes from cell division to embryogenesis to postnatal growth and maturity. (12 Dec 1998) |
| state health planning and development agencies | Agencies established under pl93-641 to coordinate, conduct, and implement state health planning activities. Two primary responsibilities are the preparation of an annual state health plan and giving assistance to the statewide health coordinating council. (12 Dec 1998) |
| land conservation and development commission | (LCDC) A commission appointed to determine land use policy in Oregon. (05 Dec 1998) |
| antisense | <molecular biology> In general the complementary strand of a coding sequence of DNA (antisense DNA) or of mRNA (antisense RNA). A collection of nucleotide sequences which are not templates for synthesis but yet interact with complementary sequences in other molecules thereby causing function of those molecules to be affected. Antisense RNA hybridises with and inactivates mRNA. (12 Dec 1998) |
| antisense DNA | <molecular biology> A synthetic DNA strand that is complementary to a particular strand of target DNA with a complementary sequence of bases. This results in preventing expression of the gene encoded. These proteins can be used to selectively turn off production of certain proteins or block viral genetic instructions, by marking them for destruction by cellular enzymes, in order to prevent the building of new virus or the infection of new cells. (14 Nov 1997) |
| antisense RNA | <molecular biology> A complementary RNA sequence that binds to (and thus blocks the transcription of) a naturally-occuring (sense) messenger RNA molecule. These proteins can be used to selectively turn off production of certain proteins or block viral genetic instructions, by marking them for destruction by cellular enzymes, in order to prevent the building of new virus or the infection of new cells. (09 Oct 1997) |
| antisense strand | <molecular biology> The strand of DNA which is not used during transcription to make mRNA (anticoding strand). The mRNA made during transcription thus has the same sequence as this strand, so that the eventual protein will be a sense version. (13 Jan 1998) |
| antisense therapy | Use of antisense DNA for the inhibition of translation of a specific gene product for therapeutic purposes. (05 Mar 2000) |
| RNA, antisense | An RNA molecule which, by binding to a complementary sequence in either RNA or DNA, inhibits the function and/or completion of synthesis of the latter molecule. It is involved in various regulatory systems in vivo. Artificial antisense rnas have been used to inhibit translation of specific mRNA molecules both in living cells (eukaryotic and bacterial) and in cell-free systems. (12 Dec 1998) |
| DNA, antisense | A DNA molecule which is complementary to the sense strand (that which functions as a template for the synthesis of mRNA) but is not involved in transcription. Both strands are involved in replication. (12 Dec 1998) |
| oligonucleotides, antisense | Short fragments (usually between 2 and 12 nucleotides) of DNA or RNA that are used to hinder or block the translation or processing of mRNA. (12 Dec 1998) |
| Venereal Disease Research Laboratory | <microbiology> A blood test used to diagnose syphilis. Read as nonreactive or negative if you do not have syphilis. The Venereal Disease Research Laboratory can also be positive is cases of leprosy, malaria, mononucleosis, lupus, hepatitis A and pregnancy. Positive Venereal Disease Research Laboratory tests are usually followed up by a more specific test (FTA antibodies). (12 Jan 1998) |
| Medical Research Council | <organisation> A UK Government funded body to promote the balanced development of medical and related biological research in the United Kingdom. It organises national clinical trials for the assessment of new treatment protocols for leukaemia and some of the related diseases. (05 Jan 1998) |
| research | Careful, a diligent search, a close searching, studious inquiry or examination. (18 Nov 1997) |