| anaphylaxis | <pharmacology> As opposed to prophylaxis. A system or treatment that leads to damaging effects on the organism. <immunology> Now reserved for those inflammatory reactions resulting from combination of a soluble antigen with IgE bound to a mast cell that leads to degranulation of the mast cell and release of histamine and histamine like substances, causing localised or global immune reponses. Results in an acute allergic reaction with shortness of breath, rash, wheezing, hypotension. See: hypersensitivity. (18 Nov 1997) |
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| active anaphylaxis | Reaction following inoculation of antigen in a subject previously sensitised to the specific antigen, in contrast to passive anaphylaxis. (05 Mar 2000) |
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| aggregate anaphylaxis | <pharmacology> As opposed to prophylaxis. A system or treatment that leads to damaging effects on the organism. <immunology> Now reserved for those inflammatory reactions resulting from combination of a soluble antigen with IgE bound to a mast cell that leads to degranulation of the mast cell and release of histamine and histamine like substances, causing localised or global immune reponses. Results in an acute allergic reaction with shortness of breath, rash, wheezing, hypotension. See: hypersensitivity. (18 Nov 1997) |
| antiserum anaphylaxis | A reaction resulting from inoculation of antigen in an animal previously inoculated intravenously with specific antiserum from another animal, a latent period being required between the two inoculations. Synonym: antiserum anaphylaxis. (05 Mar 2000) |
| generalised anaphylaxis | The immediate response, involving smooth muscles and capillaries throughout the body of a sensitised individual, that follows intravenous (and occasionally intracutaneous) injection of antigen (allergen). See: anaphylactic shock. Synonym: systemic anaphylaxis. (05 Mar 2000) |
| passive anaphylaxis | A reaction resulting from inoculation of antigen in an animal previously inoculated intravenously with specific antiserum from another animal, a latent period being required between the two inoculations. Synonym: antiserum anaphylaxis. (05 Mar 2000) |
| passive cutaneous anaphylaxis | An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. Pca is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity. (12 Dec 1998) |
| passive cutaneous anaphylaxis test | An animal is injected intradermally with antibody (usually IgE) and subsequently challenged intravenously with a mixture of antigen and Evans blue dye 24-48 hours later. A dark blue area indicates a positive reaction due to the leakage of the dye at the site of antigen-antibody reactions. (05 Mar 2000) |
| reversed anaphylaxis | An anaphylactic reaction induced in an animal injected with a specific antigen, which will bind to reactive tissue, and then, after a latent period, with serum from another animal previously sensitised to the identical antigen. Synonym: reversed anaphylaxis. (05 Mar 2000) |
| reversed passive anaphylaxis | An anaphylactic reaction induced in an animal injected with a specific antigen, which will bind to reactive tissue, and then, after a latent period, with serum from another animal previously sensitised to the identical antigen. Synonym: reversed anaphylaxis. (05 Mar 2000) |
| pharmacologic mediators of anaphylaxis | Substances released from mast (and other) cells by the reaction of antigen and specific homocytotropic antibody on their surfaces; they include histamine, slow-reacting substance of anaphylaxis (SRS-A), bradykinin, and (in some species of animals) serotonin. (05 Mar 2000) |
| chronic anaphylaxis | A haemorrhagic and necrotizing inflammation developing in the ileum (and also the colon) of sensitised dogs when they are fed a second dose of the sensitizing material. Synonym: chronic anaphylaxis. (05 Mar 2000) |
| slow-reacting factor of anaphylaxis | Slow-reacting substance of anaphylaxis (SRS-A), a leukotriene of low molecular weight which is released in anaphylactic shock and produces slower and more prolonged contraction of muscle than does histamine; it is active in the presence of antihistamines (but not epinephrine) and seems not to occur preformed in mast cells, but as a result of an antigen-antibody reaction on the granules. Compare: peptidyl leukotrienes. Synonym: slow-reacting factor of anaphylaxis. (05 Mar 2000) |
| slow reacting substance of anaphylaxis | <immunology> Potent bronchoconstrictor and inflammatory agent released by mast cells, an important mediator of allergic bronchial asthma. A mixture of three leukotrienes (LTC4 mainly, LTD4 and LTE4) (18 Nov 1997) |
| systemic anaphylaxis | The immediate response, involving smooth muscles and capillaries throughout the body of a sensitised individual, that follows intravenous (and occasionally intracutaneous) injection of antigen (allergen). See: anaphylactic shock. Synonym: systemic anaphylaxis. (05 Mar 2000) |
| inverse anaphylaxis | Anaphylactic shock in an animal (e.g., guinea pig) whose tissues contain Forssman antigen, resulting from an intravenous injection of serum that contains Forssman's antibody. (05 Mar 2000) |