| drug-drug interaction | The effects that occur when two or more drugs are used together. Such effects include changes of absorption in the digestive tract, changes in rate of the drugs' breakdown in the liver, new or enhanced side effects and changes in the drugs' activity. (09 Oct 1997) |
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| adjuvant analgesic | <pharmacology> A drug that is not a primary analgesic but that research has shown to have independent or additive analgesic properties. (16 Dec 1997) |
| analgesic | An agent that alleviates pain without causing loss of consciousness. (18 Nov 1997) |
| analgesic cuirass | An analgesic or hypalgesic zone in the proximal thoracic region, found in tabetic neurosyphilis. Synonym: analgesic cuirass, Hitzig's girdle. (05 Mar 2000) |
| analgesic nephritis | Chronic interstitial nephritis with renal papillary necrosis, occurring in patients with a long history of excessive consumption of analgesics, especially those containing phenacetin. Synonym: analgesic nephropathy. (05 Mar 2000) |
| analgesic nephropathy | <nephrology, pathology> A form of kidney damage which can occur from the overexposure to certain analgesics (for example acetaminophen, salicylates and non-steroidal anti-inflammatory agents). In most cases analgesic use is excessive in dosing or chronicity of use. Complications include acute renal failure. See: interstitial nephritis. Origin: Gr. Pathos = disease (27 Sep 1997) |
| narcotic analgesic agent | <pharmacology> Medications that relieve pain but have addictive potential if used regularly. Examples include: meperidine, morphine, propoxyphene, codeine, hydrocodone, oxycodone, hydromorphone, nalbuphine, butorphanol and heroin. (27 Sep 1997) |
| abnormalities, drug-induced | Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. (12 Dec 1998) |
| activity, drug | A measure of the physiological response a drug produces in the body. A less active drug produces less response (and visa versa). (12 Dec 1998) |
| addictive drug | Any drug that creates a certain degree of euphoria and has a strong potential for addiction. (05 Mar 2000) |
| adverse drug reaction reporting systems | Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions. (12 Dec 1998) |
| akathisia, drug-induced | Motor restlessness with sensations of quivering and an urge to move about constantly resulting from the use of certain drugs, such as neuroleptic drugs, which affect the extrapyramidal region of the brain. This differs from dyskinesia, drug-induced in that long-term antipsychotic drug exposure is significantly correlated with the increased prevalence of akathisia while there is no such correlation with dyskinesia. The primary observable distinction between tardive akathisia and dyskinesia appears to be in the repetitive, stereotypy of the dyskinesic movements (lip smacking, for example), while akathisia is associated with anxiety, restlessness, and agitation (psychomotor agitation). (12 Dec 1998) |
| antineoplastic drug | A drug that stops or slows the maturation and spread of tumour cells (benign or malignant). (09 Oct 1997) |
| maintenance drug therapy | In chemotherapy, systematic dosage at a level that maintains protection against exacerbation. (05 Mar 2000) |
| rational drug design | <pharmacology> Modeling the molecular structure of the target of a drug, for example, an antigen, and then designing a drug that will attack it. (17 Dec 1997) |