| alu sequence | Any of a family of short (300 basepairs long) repeated sequences that occur throughout the human genome. (09 Oct 1997) |
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| Alu sequences | In the human genome a repeated, relatively conserved sequence of about 300 bp that often contains a cleavage site for the restriction enzyme AluI near the centre; about 1 million copies in the human genome. (05 Mar 2000) |
| Alu | 1. Type II restriction endonuclease, isolated from Arthrobacter luteus. The recognition sequence is 5' AG/CT 3'. 2. Alu sequences are highly repetitive sequences found in large numbers 100-500,000) in the human genome and that are cleaved more than once within each sequence by the Alu endonuclease. The Alu sequences look like DNA copies of mRNA because they have a 3' poly A tail and flanking repeats. (18 Nov 1997) |
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| alu elements | <molecular biology> A set of closely related genetic sequences, each about 300 base pairs long, in the human genome. There are 500,000 to 600,000 copies widely dispersed among all 46 chromosomes: They act as markers for human DNA sequences, although their function in the genome is unknown. The DNA fragments containing the Alu elements are formed by digesting genomic DNA with the restriction endonuclease Alu I. (14 Nov 1997) |
| alu-equivalent family | A set of sequences in a mammalian genome that is related to the human Alu family. (05 Mar 2000) |
| alu family | A set of dispersed sequences in the human genome having Alu cleavage sites at each end. (05 Mar 2000) |
| amino acid sequence | The sequence of amino acids as arrayed in chains, sheets, etc., within the protein molecule. This is referred to as the primary structure of proteins. It is of fundamental importance in determining protein conformation. (12 Dec 1998) |
| autonomously replicating sequence | <molecular biology> This is a chromosomal sequence that allows plasmids to replicate on their own in yeast. (02 Jan 1998) |
| base sequence | <molecular biology> The order of nucleotide bases in a DNA molecule. (09 Oct 1997) |
| base sequence analysis | <molecular biology> A method, sometimes automated, for determining the base sequence. (09 Oct 1997) |
| canonical sequence | Of a series of related DNA, RNA or protein sequences, the sequence that reflects the most common choice of base or amino acid at each position. Areas of particularly good agreement often represent conserved functional domains. The generation of consensus sequences has been subjected to intensive mathematical analysis. (18 Nov 1997) |
| carbohydrate sequence | The sequence of carbohydrates within polysaccharides, glycoproteins, and glycolipids. (12 Dec 1998) |
| palindromic sequence | <molecular biology> Nucleic acid sequence that is identical to its complementary strand when each is read in the correct direction (e.g. TGGCCA). Palindromic sequences are often the recognition sites for restriction enzymes. Degenerate palindromes with internal mismatching can lead to loops or hairpins being formed (as in tRNA). (18 Nov 1997) |
| recognition sequence | A nucleotide sequence --typically composed of 4, 6, or 8nucleotides -- that is recognised by a restriction endonuclease. Type II enzymes cut (and theircorresponding modification enzymes methylate) within or very near the recognition sequence. (09 Oct 1997) |
| regulatory sequence | <molecular biology> DNA sequence to which regulatory molecules such as promotors or enhancers bind, thereby altering the expression of the adjacent gene. (18 Nov 1997) |
| centromeric sequence | <molecular biology> Special sequences of DNA nucleotides found on chromosomes which provide a site for the attachment of spindle fibres during nuclear division (mitosis or meiosis). (09 Oct 1997) |
| chi sequence | <molecular biology> A specific sequence of nucleotides on a site on the genome of the bacteria Escherichia coli which strongly encourages recombination and crossing over to occur at that site. (05 Jan 1998) |