| adverse drug reaction reporting systems | Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions. (12 Dec 1998) |
|---|---|
| react | 1. To return an impulse or impression; to resist the action of another body by an opposite force; as, every body reacts on the body that impels it from its natural state. 2. To act upon each other; to exercise a reciprocal or a reverse effect, as two or more chemical agents; to act in opposition. Source: Websters Dictionary (01 Mar 1998) |
| drug-drug interaction | The effects that occur when two or more drugs are used together. Such effects include changes of absorption in the digestive tract, changes in rate of the drugs' breakdown in the liver, new or enhanced side effects and changes in the drugs' activity. (09 Oct 1997) |
| adverse | Harmful. (18 Nov 1997) |
| adverse effect | This is an abnormal or harmful effect to an organism caused by exposure to a chemical. It is indicated by some result such as death, a change in food or water consumption, altered body and organ weights, altered enzyme levels, or visible illness. An effect may be classed as adverse if it causes functional or anatomical damage, causes irreversible change in the homeostasis of the organism, or increases the susceptibility of the organism to other chemical or biological stress. A non-adverse effect will usually be reversed when the organism is no longer being exposed to the chemical. (09 Oct 1997) |
| adverse event | A toxic reaction to a medical therapy. (09 Oct 1997) |
| adverse reaction | Any undesirable or unwanted consequence of a preventive, diagnostic, or therapeutic procedure or regimen. (05 Mar 2000) |
| no-observed-adverse-effect level | The highest dosage administered that does not produce toxic effects. The noael will depend on how closely dosages are spaced (lowest-observed-adverse-effect level and no-observed-effect level) and the number of animals examined. The ultimate objective is usually to determine not the "safe" dosage in laboratory animals but the "safe" dosage for humans. Therefore, the extrapolation most often required of toxicologists is from high-dosage studies in laboratory animals to low doses in humans. (casarett and doull's toxicology: the basic science of poisons, 4th ed) (12 Dec 1998) |
| event, adverse | In pharmacology, an adverse event is any unexpected or dangerous reaction to a drug. (12 Dec 1998) |
| aq bull | <abbreviation> L. Aqua bulliens, boiling water. (05 Mar 2000) |
| bull | Of or pertaining to a bull; resembling a bull; male; large; fierce. Bull bat, the pine snake of the United States. Bull stag, a castrated bull. See Stag. Bull wheel, a wheel, or drum, on which a rope is wound for lifting heavy articles, as logs, the tools in well boring, etc. 1. A seal. See Bulla. 2. A letter, edict, or respect, of the pope, written in Gothic characters on rough parchment, sealed with a bulla, and dated "a die Incarnationis," i. E, "from the day of the Incarnation." See Apostolical brief, under Brief. "A fresh bull of Leo's had declared how inflexible the court of Rome was in the point of abuses." (Atterbury) 3. A grotesque blunder in language; an apparent congruity, but real incongruity, of ideas, contained in a form of expression; so called, perhaps, from the apparent incongruity between the dictatorial nature of the pope's bulls and his professions of humility. "And whereas the papist boasts himself to be a Roman Catholic, it is a mere contradiction, one of the pope's bulls, as if he should say universal particular; a Catholic schimatic." (Milton) The Golden Bull, an edict or imperial constitution made by the emperor Charles IV. (1356), containing what became the fundamental law of the German empire; so called from its golden seal. Synonym: See Blunder. Origin: OE. Bulle, fr. L. Bulla bubble, stud, knob, LL, a seal or stamp: cf. F. Bulle. Cf. Bull a writing, Bowl a ball, Boil. 1. <zoology> The male of any species of cattle (Bovidae); hence, the male of any large quadruped, as the elephant; also, the male of the whale. The wild bull of the Old Testament is thought to be the oryx, a large species of antelope. 2. One who, or that which, resembles a bull in character or action. 3. <astronomy> Taurus, the second of the twelve signs of the zodiac. A constellation of the zodiac between Aries and Gemini. It contains the Pleiades. "At last from Aries rolls the bounteous sun, And the bright Bull receives him." (Thomson) 4. One who operates in expectation of a rise in the price of stocks, or in order to effect such a rise. See 4th Bear. Bull baiting, the practice of baiting bulls, or rendering them furious, as by setting dogs to attack them. John Bull, a humorous name for the English, collectively; also, an Englishman. "Good-looking young John Bull." . To take the bull by the horns, to grapple with a difficulty instead of avoiding it. Origin: OE. Bule, bul, bole; akin to D. Bul, G. Bulle, Icel. Boli, Lith. Bullus, Lett. Bollis, Russ. Vol'; prob. Fr. The root of AS. Bellan, E. Bellow. Source: Websters Dictionary (01 Mar 1998) |
| bull brier | <botany> A species of Smilax (S. Pseudo-China) growing from new Jersey to the Gulf of Mexico, which has very large tuberous and farinaceous rootstocks, formerly used by the Indians for a sort of bread, and by the negroes as an ingredient in making beer. Synonym: bamboo brier and China brier. Source: Websters Dictionary (01 Mar 1998) |
| bull neck | A heavy thick neck caused by hypertrophied muscles or enlarged cervical lymph nodes. (05 Mar 2000) |
| bull's-eye | 1. A small circular or oval wooden block without sheaves, having a groove around it and a hole through it, used for connecting rigging. 2. A small round cloud, with a ruddy center, supposed by sailors to portend a storm. 3. A small thick disk of glass inserted in a deck, roof, floor, ship's side, etc, to let in light. 4. A circular or oval opening for air or light. 5. A lantern, with a thick glass lens on one side for concentrating the light on any object; also, the lens itself. 6. <astronomy> Aldebaran, a bright star in the eye of Taurus or the Bull. 7. The center of a target. 8. A thick knob or protuberance left on glass by the end of the pipe through which it was blown. 9. A small and thick old-fashioned watch. Source: Websters Dictionary (01 Mar 1998) |
| bull's-eye maculopathy | An ocular condition in which oedema or degeneration of the sensory retina at the posterior pole of the eye causes alternating areas of light and dark, as in a target; seen in toxic, inflammatory, and hereditary conditions. (05 Mar 2000) |