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Addison's d. a chronic type of adrenocortical insufficiency, characterized by hypotension, weight loss, anorexia, weakness, and a bronzelike hyperpigmentation of the skin. It is due to tuberculosis- or autoimmune-induced destruction of the adrenal cortex, which results in deficiency of aldosterone and cortisol and is fatal in the absence of replacement therapy. See also addisonian crisis, under crisis. Called also chronic adrenocortical insufficiency and primary adrenal or primary adrenocortical insufficiency.
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