| 1-pyrroline-5-carboxylate dehydrogenase |
[EC 1.5.1.12] an enzyme of the oxidoreductase class that catalyzes the dehydrogenation of Δ1-pyrroline 5-carboxylate to glutamate, using NAD+ as an electron acceptor; the reaction is a step in the degradation of proline and excess ornithine. The enzyme can also oxidize the 3-hydroxy derivative of Δ1-pyrroline 5-carboxylate to form 4-hydroxyglutamate. Deficiency of the enzyme, an autosomal recessive trait, is the cause of hyperprolinemia, type II.
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