β-N- |
[EC 3.2.1.52] a lysosomal enzyme of the hydrolase class that catalyzes the cleavage of N-acetylhexosamine residues from gangliosides or other glycosides; it is necessary for the degradation of keratan sulfate and also ganglioside GM2 and related compounds. The enzyme comprises two polypeptide chains, α and β, which are arranged into three isozymes: A (αβ), B (ββ), and S (αα). Lack of isozyme A activity, due to a defect in the α chain, causes Tay-Sachs disease and other forms of GM2 gangliosidosis, variant B; lack of isozymes A and B, due to a defect in the β chain, causes Sandhoff's disease. The enzyme is usually called hexosaminidase and has been shown to be identical to β-D-acetylglucosaminidase.
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A |
absorbance; activity (def. 3); admittance; area; mass number.
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Acanthamoeba |
keratitis due to infection by Acanthamoeba spp.; it is usually associated with soft contact lens wear, particularly overnight wear.
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Ascaris |
the most common type of Löffler's syndrome, caused by presence in the lungs of the nematode Ascaris lumbricoides. Called also pulmonary ascariasis.
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B |
magnetic flux density.
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