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T-cell <haematology, immunology> A class of lymphocytes, so called because they are derived from the thymus and have been through thymic processing. Involved primarily in controlling cell-mediated immune reactions and in the control of B-cell development. The T-cells coordinate the immune system by secreting lymphokine hormones.
There are 3 fundamentally different types of t cells : helper, killer, and suppressor. Each has many subdivisions. T-cells are also called t lymphocytes.
They bear T-cell antigen receptors (CD3) and lack Fc or C3b receptors. Major T-cell subsets are CD4 (mainly helper cells) and CD8 (mostly cytotoxic or suppressor T-cells). Uncontrolled proliferation of this type of cell gives rise to T-cell leukaemia/lymphoma.
(21 Jun 1999)
T-cell antigen receptors Receptors present on T-cells that interact with both processed antigen and major histocompatibility antigens simultaneously.
(05 Mar 2000)
T-cell growth factor <cytokine> A hormone-like substance released by stimulated T lymphocytes, causes activation and differentiation of other T lymphocytes independently of antigen.
A type of interleukin, a chemical messenger, a substance that can improve the body's response to disease. It stimulates the growth of certain disease-fighting blood cells in the immune system.
It is secreted by Thl CD4 cells to stimulate CD8 cytotoxic T-1yrnphocytes. Interleukin 2 also increases the proliferation and maturation of the CD4 cells themselves. During HIV infection, Interleukin-2 production gradually declines.
Use of interleukin 2 therapy is under study as a way to raise CD4 cell counts and restore immune function.
Acronym: IL-2
(12 Dec 1998)
T-cell growth factor-1 <cytokine> A hormone-like substance released by stimulated T lymphocytes, causes activation and differentiation of other T lymphocytes independently of antigen.
A type of interleukin, a chemical messenger, a substance that can improve the body's response to disease. It stimulates the growth of certain disease-fighting blood cells in the immune system.
It is secreted by Thl CD4 cells to stimulate CD8 cytotoxic T-1yrnphocytes. Interleukin 2 also increases the proliferation and maturation of the CD4 cells themselves. During HIV infection, Interleukin-2 production gradually declines.
Use of interleukin 2 therapy is under study as a way to raise CD4 cell counts and restore immune function.
Acronym: IL-2
(12 Dec 1998)
T-cell growth factor-2 <cytokine> A soluble cytokine factor produced by activated T-lymphocytes that promotes antibody production by causing proliferation and differentiation of B-cells.
Interleukin-4 induces the expression of class II major histocompatibility complex and fc receptors on B-cells. It also acts on T-lymphocytes, mast cell lines, and several other haematopoietic lineage cells including granulocyte, megakaryocyte, and erythroid precursors, as well as macrophages.
Acronym: IL-4
(12 Dec 1998)
T-cell leukaemia virus human T-lymphotropic virus
T-cell lymphoma A cancer of the immune system that appears in the skin; also called mycosis fungoides.
(12 Dec 1998)
T-cell protein tyrosine phosphatase <enzyme> Contains a single ptp domain and possesses a c-terminal region that may play a role in enzymatic regulation and/or targeting to discrete intracellular sites; amino acid sequence known
Registry number: EC 3.1.3.-
Synonym: tc-ptp
(26 Jun 1999)
T-cell receptor <immunology> The antigen recognising receptor on the surface of T-cells. Heterodimeric (disulphide linked), one of the immunoglobulin superfamily of proteins, binds antigen in association with the major histocompatibility complex (MHC), leading to the activation of the cell.
There are two subunits (_ and _, 42-44 kD in mouse, 50-40 kD in humans), each with variable and constant regions, that are associated noncovalently with T3 (20-30 kD). A second heterodimer on CD3 cells with _ (35 kD in mice, 55 kD in humans) and _ (45 kD in mice, 40 kD in humans) chains is a second T-cell antigen receptor that is not MHC restricted. The __ T-cell receptors (TCRs) are formed on very early T-cells in the thymus.
(18 Nov 1997)
T-cell-rich, B-cell lymphoma <tumour> A B-cell lymphoma in which more than 90% of the cells are of T-cell origin, masking the large cells that form the neoplastic B-cell component.
See: adult T-cell lymphoma.
(05 Mar 2000)
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  • T-Cell Antigen Receptor Specificity - »õâ The property of the T-CELL RECEPTOR which enables it to react with some antigens and not others. The specificity is derived from the structure of the receptor's variable region which has the ability to recognize certain antigens in conjunction with the MAJOR HISTOCOMPATIBILITY COMPLEX molecule.
    Synonyms : T-Cell Receptor Specificity, Immunologic Specificity, T-Cell, Specificity, T-Cell, Specificity, T-Cell Immunologic, Specificity, T-Cell Receptor, T Cell Antigen Receptor Specificity, T Cell Immunologic Specificity, T Cell Receptor Specificity
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T-cell receptor Surface protein of T lymphocyte cells that allow the T cells to recognize infected host cells.
Ãâó: helios.bto.ed.ac.uk/bto/glossary/tuvwxyz.htm
T-cell receptor A structure on the surface of every T-cell that acts as a docking bay for antigens. A T-cell has around 20,000 copies of the same receptor dotted all over its surface.
Ãâó: www.aidsinfonyc.org/hivplus/issue9/report/glossary...
T-cell growth factor II Interleukin-4.
Ãâó:
T-cell growth f. former name for interleukin-2.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
T-cell l.’s a heterogenous group of lymphoid tumors representing malignant transformation of the T lymphocytes. The category includes convoluted T-cell lymphoma, cutaneous T-cell lymphoma, adult T-cell leukemia, and certain other conditions. Some types of tumors formerly included in this group have been found to be mixtures of T cells and B cell precursors.
Ãâó: www.mercksource.com/pp/us/cns/cns_health_library.j...
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