| APPS | amyloid precursor protein secretase |
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| secretase | <enzyme> Hypothetical proteinase which cleaves amyloid beta-precursor protein in betaa4 domain (residue 16) to generate the secreted form of app; comes in three putative forms (alpha, beta, gamma); beta and gamma forms form beta-protein from precursor, while alpha form cleaves precursor in middle so no beta-protein forms Registry number: EC 3.4.99.- Synonym: app secretase, amyloid precursor protein secretase, alpha-secretase, beta-secretase, gamma-secretase (26 Jun 1999) |
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| angiotensin-converting enzyme secretase | <enzyme> Converts ace from a membrane-bound to a soluble form; not inhibited by thiol, serine or acid enzyme inhibitor but is inhibited by edta and 1,10-phenanthroline Registry number: EC 3.4.99.- Synonym: ace secretase (26 Jun 1999) |
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| secretase | a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's) |
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