| proto-oncogene | <molecular biology> The normal, cellular equivalent of an oncogene, thus usually a gene involved in the signalling or regulation of cell growth. In general, cellular proto-oncogenes are prefixed with a c, rather than their abnormal viral counterparts, that are prefixed with a v, for example c myc and v myc. They are fragments of DNA, related to oncogenes but are the normal switches used to control growth and tissue repair. (06 Oct 1997) |
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| proto-oncogene protein p21(ras) | Cellular protein encoded by the c-ras genes. The protein has GTPase activity and is involved in transmembrane signal transduction as a guanine nucleotide binding protein. Elevated levels of p21 c-ras have been associated with neoplasia. (12 Dec 1998) |
| proto-oncogene protein pp60(c-src) | <enzyme> Membrane-associated tyrosine-specific kinase encoded by the c-src genes. It has an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to pp60(v-src) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase. Registry number: EC 2.7.1.- (12 Dec 1998) |
| proto-oncogene proteins | Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity. (12 Dec 1998) |
| proto-oncogene proteins c-abl | Membrane proteins encoded by the c-abl genes. They exhibit tyrosine kinase activity and play a role in normal haematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific n-terminal amino acids are deleted, releasing the kinase from negative regulation. (12 Dec 1998) |
| proto-oncogene proteins c-bcl-2 | Membrane proteins encoded by the bcl-2 genes and serving as a potent inhibitor of cell death by apoptosis. The proteins are found on mitochondrial, microsomal, and nuclear membrane sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (12 Dec 1998) |
| proto-oncogene proteins c-erbb-2 | Cellular proteins in the epidermal growth factor receptor family encoded by the c-erbb genes. These proteins are overexpressed in a significant portion of adenocarcinomas found at various sites, especially in the breast. Gene amplification appears to be the predominant method leading to overexpression. (12 Dec 1998) |
| proto-oncogene proteins c-fos | Cellular DNA-binding proteins encoded by the c-fos genes (genes, fos). They are involved in growth-related transcriptional control. C-fos combines with c-jun (proto-oncogene proteins c-jun) to form a c-fos/c-jun heterodimer (transcription factor ap-1) that binds to the tre (tpa-responsive element) in promoters of certain genes. (12 Dec 1998) |
| proto-oncogene proteins c-jun | Cellular DNA-binding proteins encoded by the c-jun genes (genes, jun). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun. (12 Dec 1998) |
| proto-oncogene proteins c-kit | Tyrosine kinase membrane receptors which are the natural ligands for mast cell growth factor (steel factor). This interaction is crucial for the development of haematopoietic, gonadal, and pigment stem cells. (12 Dec 1998) |
| proto-oncogene proteins c-met | <enzyme> A transmembrane tyrosine kinase that is the receptor for hepatocyte growth factor (scatter factor). It consists of an extracellular alpha chain which is disulfide linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and critical sites for the regulation of kinase activity. Registry number: EC 2.7.11.- (12 Dec 1998) |
| proto-oncogene proteins c-mos | Cellular proteins encoded by the c-mos genes (genes, mos). They function in the cell cycle to maintain maturation-promoting factor in the active state and have protein-serine/threonine kinase activity. Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time. (12 Dec 1998) |
| proto-oncogene proteins c-myc | Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumourigenesis. (12 Dec 1998) |
| proto-oncogene proteins c-raf | <enzyme> A class of serine-threonine kinases involved in cellular signal transduction. Included in this class are the proto-oncogene proteins mil and raf. Raf is a component of a signal transduction pathway leading to increased gene expression through the c-jun DNA binding site, ap1. Registry number: EC 2.7.10.- (12 Dec 1998) |
| proto-oncogenes | Normal cellular genes homologous to viral oncogenes. The products of proto-oncogenes are important regulators of biological processes and appear to be involved in the events that serve to maintain the ordered procession through the cell cycle. Proto-oncogenes have names of the form c-onc. (12 Dec 1998) |
Synonyms : Ets-1 Transcription Factor, Proto-Oncogene Proteins c-ets-1, c-ets1 Transcription Factor, Ets 1 Transcription Factor, Proto Oncogene Protein c ets 1, Proto Oncogene Protein ets 1, Proto Oncogene Proteins c ets 1, Transcription Factor, Ets-1, c ets 1 Protein
Synonyms : Proto-Oncogene Proteins c-ets-2, Proto-Oncogene Proteins ets-2, Proto Oncogene Protein c ets 2, Proto Oncogene Proteins c ets 2, Proto Oncogene Proteins ets 2, c ets 2 Protein, c-ets-2, Proto-Oncogene Protein, c-ets-2, Proto-Oncogene Proteins
Synonyms : Friend Leukemia Integration 1 Transcription Factor, Proto-Oncogene Proteins c-fli-1, Retroviral Integration Site Protein Fli-1, Proto Oncogene Protein c fli 1, Proto Oncogene Proteins c fli 1, Retroviral Integration Site Protein Fli 1
Synonyms : Proto Oncogene Proteins, Cellular, Proto-Oncogene Products, Cellular, Cellular Proto Oncogene Proteins, Cellular Proto-Oncogene Products, Proto Oncogene Products, Cellular, Proto Oncogene Proteins, Proto-Oncogene Proteins, Cellular, c onc Proteins
Synonyms : A-raf Kinase, A-raf Protein Kinase, A-raf-1 Protein, Proto-Oncogene Protein A-raf, A raf 1 Protein, A raf Kinase, A raf Protein Kinase, Kinase, A-raf, Kinase, A-raf Protein, Proteins A-raf, Proto-Oncogene, Proto Oncogene Protein A raf
| proto-oncogene |
a normal gene that has the potential to become an oncogene
출처: wordnet.princeton.edu/perl/webwn
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| proto-oncogene |
(pro
출처: www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspz...
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| proto-oncogene |
a normal cellular gene that is activated to become an oncogene by mutation, deletion, rearrangement over expression or inappropriate expression.
출처: www.geocities.com/HotSprings/3982/dictionary.html
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| proto-oncogene |
a gene that is normally inactive but can become a cancer-causing oncogene if made active
출처: www.american-depot.com/services/resources_gl_p.asp
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| proto-oncogene |
Normal cellular gene, usually involved in growth control, from which an oncogene is derived as the result of a somatic mutation or viral recombination.
출처: www.genpromag.com/Glossary~LETTER~P.html
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| proto-oncogene | a normal gene that has the potential to become an oncogene |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
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