| meiotic nondisjunction | Failure of two memberrs of a chromosome pair to separate (disjoin) during meiosis so that both go to one daughter cell and none to the other. This mechanism is responsible for the extra chromosome 21 in trisomy 21 (down syndrome) and for extra and missing chromosomes causing other birth defects and many spontaneous abortions (miscarriages). (12 Dec 1998) |
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| mitotic nondisjunction | Failure of the two members of a chromosome pair to separate (disjoin) during mitosis so that both go to one daughter cell and none to the other. (12 Dec 1998) |
| primary nondisjunction | Nondisjunction occurring in a previously normal cell. (05 Mar 2000) |
| secondary nondisjunction | Nondisjunction occurring in an aneuploid cell that was the result of a primary nondisjunction. (05 Mar 2000) |
| nondisjunction | <genetics, molecular biology> Failure of homologous chromosomes or sister chromatids to separate or segregate at meiosis or mitosis respectively. It results in aneuploid cells, where the daughter cell has two chromosomes or two chromatids and the other has none. Nondisjunction of the X chromosome in Drosophila confirmed the theory of chromosomal inheritance. (17 Jul 2002) |
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