| FKBP | FK 506 [macrolide] binding protein |
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| MLS | Macrolide-lincosamide-streptogramin B |
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| MLS | macrolide-lincosamide-streptogramin |
| MLS(B) | macrolide-lincosamide-streptogramin B |
| macrolide | <pharmacology> A group of antibiotics produced by various strains of Streptomyces that have a complex macrocyclic structure. They inhibit protein synthesis by blocking the 50S ribosomal subunit. Include erythromycin, carbomycin. Used clinically as broad spectrum antibiotics, particularly against gram-positive bacteria. (18 Nov 1997) |
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| macrolide 2'-kinase | <enzyme> Inducible intracellular enzyme which inactivates 14-member ring macrolides at the 2'-oh of the d-desosamine moiety; from an erythromycin-resistant strain of E coli; GTP, itp and ATP can also act as donors; mph(2')i is encoded by mpha and mrx, which have been sequenced Registry number: EC 2.7.1.136 Synonym: oleandomycin 2'-phosphotransferase, macrolide 2'-phosphotransferase, macrolide 2'-phosphotransferase I, mph(2')i (26 Jun 1999) |
| macrolide glycosyltransferase | <enzyme> From streptomyces lividans; utilises udp-glucose as cofactor; substrates include macrolides with 12-, 14-, 15-, or 16-atom cyclic polyketide lactones; enzyme specific for the 2'-oh group of saccharide moieties attached to c-5 of the 16-atom lactone ring Registry number: EC 2.4.1.- Synonym: macrolide glucosyltransferase (26 Jun 1999) |
| macrolides | A group of organic compounds that contain a macrocyclic lactone ring linked glycosidically to one or more sugar moieties. (12 Dec 1998) |
| antibiotics, macrolide | A group of antibiotics containing a macrocyclic lactone ring linked glycosidically to one or more sugar moieties. These antibiotics are produced by certain species of streptomyces. They often inhibit protein synthesis by binding to the 50s subunits of 70s ribosomes. (12 Dec 1998) |
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Synonyms : Macrolide Ketolides, Macrolide Polyketides, Polyketide Macrolides, Ketolides, Macrolide, Macrolides, Polyketide, Polyketides, Macrolide
| macrolide |
1. a chemical compound characterized by a large lactone ring containing multiple keto and hydroxyl groups. 2. any of a large group of antibacterial antibiotics containing a macrolide ring linked glycosidically to one or more sugars; they are produced by certain species of Streptomyces and inhibit protein synthesis by binding to the 50S subunits of 70S ribosomes. Examples include erythromycin, azithromycin, and clarithromycin.
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