| PNH | Paroxysmal Nocturnal Haemoglobinuria |
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| PCH | Paroxysmal cold haemoglobinuria |
| malarial haemoglobinuria | A condition, now uncommon, resulting from Plasmodium falciparum infection (malignant tertian malaria with severe haemolysis); frequently seen in Caucasians after interrupted treatment with quinine. Synonym: blackwater fever, haemoglobinuric fever, West African fever. (05 Mar 2000) |
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| malarial | Pertaining to or affected with malaria. (05 Mar 2000) |
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| malarial cachexia | Malaria that develops after frequently repeated attacks of one of the acute forms, usually falciparum malaria; it is characterised by profound anaemia, enlargement of the spleen, emaciation, mental depression, sallow complexion, oedema of ankles, feeble digestion, and muscular weakness. Synonym: limnaemia, malarial cachexia. (05 Mar 2000) |
| malarial crescent | The male or female gametocyte(s) of Plasmodium falciparum, whose presence in human red blood cells is diagnostic of falciparum malaria. Synonym: crescent, sickle form. Myopic crescent, a white or grayish white crescentic area in the fundus of the eye located on the temporal side of the optic disk; caused by atrophy of the choroid, permitting the sclera to become visible. Synonym: myopic conus. Sublingual crescent, the crescent-shaped area on the floor of the mouth formed by the lingual wall of the mandible and the adjacent part of the floor of the mouth. (05 Mar 2000) |
| malarial knobs | Rounded protrusions of a red blood cell infected with Plasmodium falciparum, responsible for the adhesion of infected red cells to one another and to the endothelium of the blood vessels containing these infected cells; results in capillary blockage responsible for much of the pathology of malignant tertian malaria. (05 Mar 2000) |
| malarial periodicity | A clinical rhythmicity reflected in periodic fevers and chills recurring at approximately 48-hour intervals in tertian malaria (Plasmodium vivax or P. Ovale) or at 72-hour intervals in quartan malaria (Periodicity malariae); the rhythm of tertian or 48-hour cycles is frequently modified in malignant tertian or falciparum malaria (P. Falciparum); associated with release of merozoites from red cells during erythrocytic schizogony, although the controlling mechanism for the synchronous release is unknown. (05 Mar 2000) |
| malarial pigment | A dark brown, granular pigment which rotates the plane of polarised light and has other properties similar to formalin pigment; occurs in parasites, such as Plasmodium malariae, around brain capillaries, and in fixed macrophages of spleen, liver, bone marrow, and lymph nodes. See: malarial pigment stain. (05 Mar 2000) |
| malarial pigment stain | <technique> A stain using phloxine-toluidine blue O sequence; malarial pigment and nuclei are bluish, erythrocytes and cytoplasm are red to orange; found in phagocytic cells of the reticuloendothelial system. (05 Mar 2000) |
| malignant tertian malarial parasite | A species of protozoa that is the causal agent of falciparum malaria (malaria, falciparum). It is most prevalent in the tropics and subtropics. (12 Dec 1998) |
| intermittent malarial fever | See: intermittent malaria. (05 Mar 2000) |
| bacillary haemoglobinuria | An acute toxaemic disease of cattle caused by the bacterium Clostridium haemolyticum and characterised by severe depression, fever, abdominal pain, dyspnea, dysentery, haemoglobinuria, and rapid death; also occurs in sheep and, rarely, in dogs. (05 Mar 2000) |
| bovine haemoglobinuria | An infectious disease of cattle caused by Babesia species and transmitted by ticks. Synonym: bovine haemoglobinuria, redwater fever, Texas fever, tick fever. (05 Mar 2000) |
| march haemoglobinuria | A form occurring after marathon races, protracted marching, or heavy physical exercise. (05 Mar 2000) |
| paroxysmal cold haemoglobinuria | <haematology> A rare blood disorder caused by antibodies which destroy red blood cells upon exposure to the cold. The antibodies are formed against a specific blood group and are triggered by the cold. The cause is unknown but the disease has been associated with syphilis and some viral infections. Serum haemoglobin and urine haemoglobin are increased during the attacks. The disease is chronic and treatment is difficult. Some cases resolve spontaneously without treatment. Origin: Gr. Ouron = urine (27 Sep 1997) |
| paroxysmal nocturnal haemoglobinuria | An infrequent disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterised by episodes of haemolytic anaemia, haemoglobinuria (chiefly at night), pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly; red blood cells are usually macrocytic and vary considerably in size, but there is no evidence of spherocytosis, erythrophagocytosis, or abnormal leukocytes. The disorder is a result of an abnormality of the red cell membrane which makes the red cell unusually sensitive to lysis by complement. Synonym: Marchiafava-Micheli anaemia, Marchiafava-Micheli syndrome. (05 Mar 2000) |
| postparturient haemoglobinuria | <haematology, obstetrics> A sudden, severe haemolytic disease that appears sporadically in well nourished dairy cows 2 to 4 weeks after calving, and usually occurs in stabled animals in the winter and early spring; the cause is not known, although the disease is often associated with hypophosphatemia. Synonym: puerperal haemoglobinaemia, puerperal haemoglobinuria. (05 Mar 2000) |
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