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interleukin-2 <cytokine> A hormone-like substance released by stimulated T lymphocytes, causes activation and differentiation of other T lymphocytes independently of antigen.
A type of interleukin, a chemical messenger, a substance that can improve the body's response to disease. It stimulates the growth of certain disease-fighting blood cells in the immune system.
It is secreted by Thl CD4 cells to stimulate CD8 cytotoxic T-1yrnphocytes. Interleukin 2 also increases the proliferation and maturation of the CD4 cells themselves. During HIV infection, Interleukin-2 production gradually declines.
Use of interleukin 2 therapy is under study as a way to raise CD4 cell counts and restore immune function.
Acronym: IL-2
(12 Dec 1998)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 5 ÆäÀÌÁö: 1
  • Interleukin-2 - »õâ A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.
    Synonyms : IL2, Interleukin II, Interleukine 2, RU 49637, RU-49637, Ro-23-6019, Ro-236019, T-Cell Stimulating Factor, Thymocyte Stimulating Factor, Interleukin 2, Mitogenic Factor, Lymphocyte, RU49637, Ro 23 6019, Ro 236019, Ro236019, T Cell Growth Factor
  • Interleukin-2 Receptor alpha Subunit - »õâ A low affinity interleukin-2 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-2.
    Synonyms : CD25 Antigen, IL-2Ralpha, Interleukin-2 Receptor alpha, Interleukin-2 Receptor alpha Chain, Interleukin-2Ralpha, alpha-subunit, Receptor, Interleukin-2, Antigen, CD25, IL 2Ralpha, Interleukin 2 Receptor alpha, Interleukin 2 Receptor alpha Chain
  • Interleukin-2 Receptor beta Subunit - »õâ A receptor subunit that is a shared component of the INTERLEUKIN 2 RECEPTOR and the INTERLEUKIN-15 RECEPTOR. High affinity receptor complexes are formed with each of these receptors when their respective alpha subunits are combined with this beta subunit and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
    Synonyms : CD122 Antigen, IL-2-15 Receptor-beta, IL-2R BETA, IL-2Rbeta2, Interleukin 2-15 Receptors-beta, Interleukin-2 Receptor beta, Interleukin-2 Receptor beta Chain, Interleukin-2-15 Receptor-beta, Interleukin-Binding Peptide p75, IL 2 15 Receptor beta, IL 2R BETA
  • Interleukin-21 Receptor alpha Subunit - »õâ An interleukin-21 receptor subunit that combines with the INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT to form a high affinity receptor for INTERLEUKIN-21. It signals via interaction of its cytoplasmic domain with JANUS KINASES such as JANUS KINASE 1 and JANUS KINASE 3.
    Synonyms : IL-21 Receptor alpha Chain, Interleukin-21 Receptor alpha Chain, IL 21 Receptor alpha Chain, Interleukin 21 Receptor alpha Chain, Interleukin 21 Receptor alpha Subunit
  • Interleukin-23 - »õâ A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-23 is comprised of a unique 19 kDa subunit and 40 kDa subunit that is shared with INTERLEUKIN-12. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells
    Synonyms : Interleukin 23
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interleukin-2 A type of biological response modifier (a substance that can improve the body's natural response to disease) that stimulates the growth of certain disease-fighting blood cells in the immune system. Also called IL-2.
Ãâó: nydailynews.healthology.com/nydailynews/15836.htm
interleukin-2 A naturally produced protein of the immune system that stimulates the growth of specific types of white blood cells. It is an FDA-approved immunotherapy for advanced inoperable melanoma and is under study for the adjuvant treatment of high-risk melanoma.
Ãâó: www.melanomacenter.org/glossary/i.html
interleukin-2 A hormone that is produced by both T-helper and suppressor lymphocytes (a white blood cell formed in the lymphatic tissue throughout the body). Interstitial - Space within an organ or tissue.
Ãâó: www.alahv.org/bookfiles4/glossary_of_terms.html
interleukin-2 A hormone-like substance produced by the body (certainblood cells, specifically) that stimulates the growth of blood cells important to the body's immune system.
Ãâó: www.ctrf.org/glossary.cfm
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