| DOPA, dopa | dihydroxyphenylalanine |
|---|---|
| L-DOPA, | L-dopa levodopa, levo-3, 4-dihydroxyphenylalanine |
| NQO | NAD(P)H:quinone oxidoreductase |
| DDC | L-Dopa De-Carboxylase |
| DOPA | 3,4-Dihydr-Oxy-Phenyl-Alanine |
| (18)F-DOPA | 6-[(18)F]fluoro-L-DOPA |
|---|---|
| TPQ | 2,4,5-trihydroxyphenyl)alanine quinone |
| NQO1 | NAD(H):quinone oxidoreductase |
| QR | NAD(P)H-quinone oxidoreductase |
| NQR | NAD(P)H: quinone reductase |
| dopa quinone | An oxidation product of dopa and an intermediate in the formation of melanin from tyrosine. (05 Mar 2000) |
|---|
| sodium-translocating NADH-quinone reductase | <enzyme> From vibrio alginolyticus; na+ dependent activation is located in the NADH-quinone reductase segment; reduces ubiquinone-1 to ubisemiquinones or ubiquinol; strongly inhibited by 2-n-heptyl-4-hydroxyquinoline n-oxide; do not confuse with sodium independent NADH-quinone reductase EC 1.6.99.2 Registry number: EC 1.6.5.- Synonym: nqr-1, na-translocating NADH-quinone reductase, nqr gene product (26 Jun 1999) |
|---|---|
| N-acetyldopamine-quinone isomerase | <enzyme> Enzyme from insect cuticle converts n-acetyldopamine quinone to nada quinone methide Registry number: EC 5.3.2.- Synonym: nada-quinone isomerase (26 Jun 1999) |
| NADPH dehydrogenase (quinone) | A flavoprotein similar to NADH dehydrogenase (quinone), but oxidizing NADPH. Synonym: DT-diaphorase, menadione reductase, phylloquinone reductase, quinone reductase. (05 Mar 2000) |
| NAD(p)h dehydrogenase (quinone) | <enzyme> A flavoprotein that reversibly catalyses the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. Since the enzyme is a part of the mitochondrial respiratory chain, defects or deficiencies of this enzyme are an important cause of neurological diseases such as parkinsonism. It may have a protective effect against cancer caused by quinones or their metabolic precursors. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine. Chemical name: NAD(P)H:(quinone-acceptor) oxidoreductase Registry number: EC 1.6.99.2 (12 Dec 1998) |
| sulfide quinone reductase | <enzyme> Part of the photosynthetic electron transport chain in chlorobium; reaction occurs in the dark, in the absence of oxygen Registry number: EC 1.8.5.- Synonym: plastoquinone reductase, sulfide-quinone oxidoreductase, sqr enzyme, sulfide-quinone reductase (26 Jun 1999) |
| quinone | Aromatic dicarbonyl compound derived from a dihydroxy aromatic compound. Ubiquinone (coenzyme Q) is a dimethoxy dicarbonyl derivative of benzene involved in electron transport. Other quinones may act as tanning agents. (18 Nov 1997) |
| quinone methide isomerase | <enzyme> From insect cuticle; converts 4-alkyl catechols to quinone methides Registry number: EC 5.3.2.- Synonym: o-quinone-quinone methide isomerase, 4-alkyl-o-quinone-2-hydroxy-4-quinone methide isomerase (26 Jun 1999) |
| quinone methide tautomerase | <enzyme> Enzyme from insect cuticle converts n-acetyldopamine quionone methide to 1,2-dehydro-n-acetyldopamine Registry number: EC 5.3.2.- Synonym: nada quione methide tautomerase (26 Jun 1999) |
| quinone reductase | <enzyme> Enzymes that reduce quinones to phenols usually using NADH or NADPH as a source of reducant. (18 Nov 1997) |
| quinone reductases | <enzyme> NAD(p)h:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. (NAD(p)h dehydrogenase (quinone)) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol. Registry number: EC 1.6.99. (12 Dec 1998) |
| alpha methyl dopa | <drug> An antihypertensive drug, preferred in pregnant patients. (18 Nov 1997) |
| decarboxylated dopa | <drug> A catecholamine neurotransmitter and hormone (153 D), formed by decarboxylation of dehydroxyphenylalanine (dopa). A precursor of adrenaline and noradrenaline. Pharmacologic action: 1. Precursor of norepinephrine 2. Stimulates dopaminergic, alpha and beta-1 adrenergic receptors: 3. Dopaminergic (1-2 mcg/kg per min): cerebral, renal, and mesenteric vasodilation increase urine output 4. Mixed alpha and beta-1 (2-10 mcg/kg per min): increases cardiac ouput with moderate increase systemic vascular resistance 5. Predominantly alpha (>20 mcg/kg per min): increases systemic vascular resistance Uses: 1. Treat hypotension associated with bradycardia 2. Stimulate cardiac output and urine output Dose: 1. Start infusion at 1-5 mcg/kg per min and titrate to effect. 2. Use the lowest dose that provides the desired hemodynamic improvement. 3. Do not exceed 20 mcg/kg per min. Potential complications: 1. May increase pulmonary pressure and worsen pulmonary congestion. 2. May increase myocardial work without improving coronary blood flow, exacerbating myocardial ischemia 3. Stimulates heart rate and may cause supraventricular or ventricular arrhythmias (15 Mar 2000) |
| dopa | An amino acid derived from the amino acid tyrosine. It is formed as the first intermediate in the production of dopamine, a neurotransmitter. (09 Oct 1997) |
| dopa decarboxylase | <enzyme> One of the aromatic-l-amino-acid decarboxylases, this enzyme is responsible for the conversion of dopa to dopamine. It is of clinical importance in the treatment of parkinson's disease. Registry number: EC 4.1.1.- (12 Dec 1998) |
| DOPA dioxygenase | <enzyme> Key enzyme in betalain biosynthesis pathway of amanita muscaria; genbank y12886 Registry number: EC 1.14.99.- Synonym: dopa-4,5-dioxygenase, doda gene product (26 Jun 1999) |
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