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COMT Catechol-O-Methyl Transferase
CCMT catechol methyltransferase
CDS cardiovascular surgery; catechol-3, 5-disulfonate; caudal dysplasia syndrome; Chemical Data System; ...
CMT California mastitis test; cancer multistep therapy; catechol methyltransferase; certified medical tr...
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OR Oestrogen receptor
CE 4-catechol estrogens
4MC 4-methyl catechol
C23O Catechol 2,3-dioxygenase
COMT catechol-O-methly transferase
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catechol oestrogen Any 2-hydroxylated derivative of an oestrogen; they, with their methylated derivatives, can account for up to one-half of all excreted oestrogen metabolites.
(05 Mar 2000)
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catechol A term loosely used for catechin, which contains a pyrocatechol moiety, and as the root of catecholamines, which are pyrocatechol derivatives.
Synonym: pyrocatechol.
(05 Mar 2000)
catechol 1,2-dioxygenase <enzyme> Little activity towards chlorinated substrates
Registry number: EC 1.13.11.1
Synonym: pyrocatechase, catechol-1,2-oxygenase, pyrocatechol 1,2-dioxygenase
(26 Jun 1999)
catechol 2,3-dioxygenase <enzyme> An oxidoreductase oxidizing catechol, with oxygen, to 2-hydroxymuconate saemialdehyde.
Synonym: metapyrocatechase.
(05 Mar 2000)
catechol o-methyltransferase <enzyme> An enzyme of the transferase class that catalyses the transfer of a methyl group from s-adenosylmethionine to a catechol or catecholamine such as dopa, dopamine, norepinephrine, or epinephrine. (converting to normetanephrine and metanephrine, respectively), the methyl group coming from S-adenosyl-l-methionine. An important step in the catabolism of the catecholamines.
The enzyme occurs in the cytoplasm, particularly in the kidney, liver, and central nervous system.
Chemical name: S-Adenosyl-L-methionine:catechol O-methyltransferase
Registry number: EC 2.1.1.6
(05 May 2002)
catechol oxidase <enzyme> An enzyme of the oxidoreductase class that catalyses the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols.
Chemical name: 1,2-Benzenediol:oxygen oxidoreductase
Registry number: EC 1.10.3.1
(12 Dec 1998)
oestrogens, catechol 2- or 4-hydroxyoestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an oestrogenic action or interaction with the catecholaminergic system.
(12 Dec 1998)
conjugated oestrogen <pharmacology> An amorphous preparation of naturally occurring, water-soluble, conjugated forms of mixed oestrogen's obtained from the urine of pregnant mares; the principal oestrogen present is sodium estrone sulfate; suitable for parenteral, oral, and topical administration, and used in conditions responsive to oestrogen therapy.
(05 Mar 2000)
selective oestrogen-receptor modulator <pharmacology> An antioestrogen which possesses some, but not all, of the actions of oestrogen. For example, raloxifene (evista) is classified as a SERM because it prevents bone loss (like oestrogen) and lowers serum cholesterol (like oestrogen) but (unlike oestrogen) does not stimulate the endometrial lining of the uterus.
Acronym: SERM
(17 Jul 2002)
designer oestrogen An engineered drug that possesses some, but not all, of the actions of oestrogen. Designer oestrogens are selective oestrogen-receptor modulators (SERMs). For example, raloxifene (trade name Evista) is classified as a SERM because it prevents bone loss (like oestrogen) and lowers serum cholesterol (like oestrogen) but (unlike oestrogen) does not stimulate the endometrial lining of the uterus.
(12 Dec 1998)
oestrogen <endocrinology, hormone> A generic term for oestrus producing steroid compounds, the female sex hormones.
In humans, oestrogen is formed in the ovary, possibly the adrenal cortex, the testis and the foetoplacental unit, it has various functions in both sexes. It is responsible for the development of the female secondary sex characteristics and during the menstrual cycle it acts on the female genitalia to produce an environment suitable for the fertilization, implantation and nutrition of the early embryo.
Oestrogen is used in oral contraceptives and as a palliative in cancer of the breast after menopause and cancer of the prostate, other uses include the relief of the discomforts of menopause, inhibition of lactation and treatment of osteoporosis, threatened abortion and various functional ovarian disorders.
(18 Nov 1997)
oestrogen antagonist <pharmacology> A drug or compound which inhibit or antagonise the action or biosynthesis of oestrogen.
Tamoxifen also has agonist or stimulatory actions as well as blocking effects. There are also selective oestrogen-receptor modulators (SERMs). For example, raloxifene (trade name Evista) is classified as a SERM because it prevents bone loss (like oestrogen) and lowers serum cholesterol (like oestrogen) but (unlike oestrogen) does not stimulate the endometrial lining of the uterus.
(12 May 2002)
oestrogen receptor <cell biology> Cytoplasmic proteins that bind oestrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of oestrogen receptors in breast cancer patients has become clinically important and determines the likelihood of response to anti-oestrogen therapy with tamoxifen.
(17 Jul 2002)
oestrogen replacement therapy <endocrinology, gynaecology> The use of oestrogenic substances in postmenopausal or other oestrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, dyspareunia, and progressive development of osteoporosis.
(12 Dec 1998)
testosterone-oestrogen-binding globulin A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Changes in its concentration significantly affect the ratio of unbound (biologically active) testosterone to estradiol in plasma.
(12 Dec 1998)
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