| 영문 | alkylating agent | 한글 | 알킬화약물 |
|---|---|---|---|
| 설명 | 항암제의 일종. 이상적인 항암제는 정상적인 세포에는 해를 주지 않고 단지 암세포에만 치명적인 효과를 나타내야 한다. 이렇게 하려면 암세포만의 특이한 특성을 이해하고 그곳에만 작용하는 약물을 개발해야 한다. 현재 대부분의 항암제는 암세포가 정상 세포에 비하여 월등히 증식을 빨리한다는 특성을 이용하고 있다. 증식이 빠르다는 것은 다시 말하면 유전 정보를 가지고 있는 DNA의 복제가 빠르다는 것을 의미한다. 만약 DNA의 복제를 방해한다면 증식이 아주 빠른 암세포에게는 치명적이지만 영원히 증식을 하지 않는 DNA의 복제가 거의 필요없는)신경세포나 증식이 암세포에 비해서 아주 느린 정상세포에는 거의 영향을 주지 못한다. 하지만 신체에서도 증식이 암세포와 비슷한 수준으로 일어나는 정상적인 세포가 있는데 그것은 머리카락을 만드는 모낭세포와 소화관의 점막을 이루는 세포와 혈액의 세포를 만드는 골수 세포이다. 그러므로 항암제를 사용할 경우 암세포와 마찬가지로 이들 세포도 함께 치명적인 영향을 입을 것은 당연하다(그래서 항암제 치료시엔 머리가 빠지고 소화불량이 잘 온다). 알칼화약물의 경우에는 DNA와 직접 결합을 하여 DNA의 복제를 억제함으로써 항암제의 역할을 수행한다. |
||
| AGEPC | 1-0-Alkyl-2-Acetyl-sn-Glycero-3-Phosphocholine |
|---|---|
| ALP | Alkyl lysophospholipids |
| AT | alkyl transferase |
| alkyl | 1. A hydrocarbon radical of the general formula CnH2n+1. 2. A compound, such as tetraethyl lead, in which a metal is combined with alkyl radicals. Synonym: alkide. (05 Mar 2000) |
|---|---|
| alkyl and aryl transferases | <enzyme> A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). Registry number: EC 2.5 (12 Dec 1998) |
| alkyl dihydroxyacetone phosphate oxidoreductase | <enzyme> Forms alkyl-sn-glycerol 3-phosphate, uses NADPH Registry number: EC 1.1.1.- (26 Jun 1999) |
| alkyl group | <chemistry> A funtional group on an organic molecule which is derived from an alkane which has lost a hydrogen atom. (13 Nov 1997) |
| alkyl hydroperoxide reductase | <enzyme> Reduces an alkyl hydroperoxide to the corresponding alcohol in the presence of NADPH; ahpc gene product from salmonella typhimurium Registry number: EC 1.- Synonym: ahpc gene product, alkylhydroperoxide reductase, ahpf gene product (26 Jun 1999) |
| alkylacetylglycerophosphatase | <enzyme> Involved in the synthesis of platelet-activating factor Registry number: EC 3.1.3.59 Synonym: alkylacetyl-gp phosphohydrolase, 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase (26 Jun 1999) |
| alkylamine | An alkane containing an -NH2 group in place of one H atom; e.g., ethylamine. (05 Mar 2000) |
| alkylating agent | <oncology, pharmacology> A reagent that places an alkyl group, for example propyl in place of a nucleophilic group in a molecule. Alkylating reagents include a number of cytotoxic drugs some of which react fairly specifically with N7 of the purine ring and lead to depurination of DNA, for example the agent ethyl ethanesulphonic acid and thus to mutagenesis. The drugs interaction with DNAand prevents the division of the cells. Examples of drugs include: busulphan, chlorambucil, cyclophosphamide, melphalan. (29 Sep 1997) |
| alkylating agents | Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agent, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. (12 Dec 1998) |
| alkylation | The substitution of an alkyl group for an active hydrogen atom in an organic compound. (12 Dec 1998) |
| alkyldihydroxyacetone phosphate acyltransferase | <enzyme> Catalyses acylation of alkyl-dhap Registry number: EC 2.3.1.- Synonym: adapat (26 Jun 1999) |
| alkylglycerol kinase | <enzyme> Forms 1-alkyl-2-lyso-sn-glycero-3-phosphate Registry number: EC 2.7.1.93 Synonym: alkylglycerol phosphotransferase (26 Jun 1999) |
| alkylglycerone-phosphate synthase | <enzyme> Replaces the acyl moiety of acyldhap with a long chain fatty alcohol; intact alcohol including the oxygen atom is incorporated into alkyl-dhap Registry number: EC 2.5.1.26 Synonym: adhps, alkyl-dihydroxyacetone phosphate synthase, alkyl-dhap synthase, alkyldihydroxyacetone phosphate synthetase, acylglycerone-3-phosphate-long chain-alcohol o-3-phospho-2-oxopropanyl transferase, alkyldihydroxyacetonephosphate synthase (26 Jun 1999) |
| alkylglycerophosphoethanolamine phosphodiesterase | <enzyme> From microsomal preparations of rabbit kidney medulla; hydrolyzes choline moiety from lyso-paf to form 1-alkyl-2-lysoglycerophosphate in rat brain and other tissue; only lysoglycerophospholipids with ether linkages at the sn-1 position serve as substrates; acyl analogs are not utilised; requires magnesium Registry number: EC 3.1.4.39 Synonym: lysophospholipase d (26 Jun 1999) |
| alkylhalidase | <enzyme> Acts on haloalkanes to form aldehyde and halogen(s) Registry number: EC 3.8.1.1 Synonym: haloalkane dehalogenase, 1-chlorohexane halidohydrolase, lina-like gene product, dhaa gene product (26 Jun 1999) |
| acetyl-CoA-1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase | <enzyme> Transfers acetate from acetyl CoA to the sn-2-position of 1-alkyl-2-lyso-glycerophosphocholine, forming the substrate for 1-alkylglycerophosphocholine acetyltransferase (EC 2.3.1.67) Registry number: EC 2.3.1.- Synonym: acopc acetyltransferase, 1-alkyl-2-lyso-sn-glycero-3-phosphocholine-acetyl CoA acetyltransferase, alkyllyso-gp-acetyl-CoA acetyltransferase, acetyl-coenzyme a-1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase (26 Jun 1999) |
|---|---|
| acyl-CoA-1-O-alkyl-2-acetyl-sn-glycerol acyltransferase | <enzyme> From hl-60 cells; related to platelet-activating factor metabolism Registry number: EC 2.3.1.- Synonym: acyl-CoA-1-o-hexadecyl-2-acetyl-sn-glycerol acyltransferase, acaag-acyltransferase, acyl-coenzyme a-1-o-alkyl-2-acetyl-sn-glycerol acyltransferase (26 Jun 1999) |
| 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase | <enzyme> Alkylacylglycerophosphorylethanolamine alk-1-enylacyl-glycerophosphorylethanolamine (ethanolamine plasmalogen) type of reaction (cis-olefination), cofactor requirement resembles fatty acid desaturases Registry number: EC 1.14.99.- (26 Jun 1999) |
Synonyms :
Synonyms : Alkylators, Agents, Alkylating
Synonyms : Alkylations
Synonyms : Compounds, Alkyl Mercury, Compounds, Alkylmercury, Mercury Compounds, Alkyl
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|---|---|---|---|
|
알키록산주200mg - 새창
|
중외 |
A02105101 | Cyclophosphamide | 전문의약품 | 급여 | 분업예외의약품 |
|
알키록산주500mg - 새창
|
중외 |
A02105221 | Cyclophosphamide | 전문의약품 | 급여 | 분업예외의약품 |
|
성광태고액1% - 새창
|
성광제약 |
Alkyl diaminoethyl glycine hydrochloride | 일반의약품 | 비급여 |
|
|
스킨셉트액 - 새창
|
성광제약 |
Alkyl aminoethyl glycine hydrochloride, Isopropanol | 일반의약품 | 비급여 |
|
|
알태고 - 새창
|
동인당제약 |
A17200971 | Alkyl diaminoethyl glycine hydrochloride, Ethanol | 일반의약품 | 삭제 |
|
성광태고액10% - 새창
|
성광제약 |
A03901031 | Alkyl diaminoethyl glycine hydrochloride | 일반의약품 | 삭제 |
|
태평양테고51 - 새창
|
태평양제약 |
Alkyl diaminoethyl glycine hydrochloride | 일반의약품 | 비급여 |
|
|
피고셉액 - 새창
|
동인당제약 |
Alkyl diaminoethyl glycine hydrochloride, Isopropanol | 일반의약품 | 비급여 |
|
|
성광태고액5% - 새창
|
성광제약 |
Alkyl diaminoethyl glycine hydrochloride | 일반의약품 | 비급여 |
|
|
그린안티?액 - 새창
|
그린제약 |
A60300061 | Alkyl diaminoethyl glycine hydrochloride, Isopropanol | 일반의약품 | 삭제 |
| alkyl |
any of a series of univalent groups of the general formula CnH2n+1 derived from aliphatic hydrocarbons
출처: wordnet.princeton.edu/perl/webwn
|
|---|---|
| alkylating agent |
A drug that is used in the treatment of cancer. It interferes with the cell's DNA and inhibits cancer cell growth.
출처: www.stjude.org/glossary
|
| alkylating agent |
A chemical agent that can add alkyl groups (for example, ethyl or methyl groups) to another molecule; many mutagens act through alkylation.
출처: helios.bto.ed.ac.uk/bto/glossary/ab.htm
|
| alkylating agent |
a chemical that introduces an alkyl group onto DNA; they act as carcinogens but are also used in chemotherapy.
출처: www.oup.com/uk/booksites/content/0199264724/studen...
|
| alkylating agent |
This is a term that describes any substance that introduces an alkyl radical into a compound in place of a hydrogen atom.
출처: www.bio.hw.ac.uk/edintox/glossall.htm
|
| alkyl | any of a series of univalent groups of the general formula CnH2n+1 derived from aliphatic hydrocarbons |
|---|---|
| alkyl | any of a series of univalent groups of the general formula CnH2n+1 derived from aliphatic hydrocarbons |
| alkyl | organic compound in which halogen atoms have been substituted for hydrogen atoms in an alkane |
| alkyl | any of a series of univalent groups of the general formula CnH2n+1 derived from aliphatic hydrocarbons |
| alkyl | organic compound that has an alkyl group bound to a benzene ring |
| alkyl | sulfonate of alkyl benzene |
| alkyl | (chemistry) of or related to an alkyl |
제품명 |
판매사 |
보험코드 | 성분/함량 | 구분/보험급여 |
|---|
