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syndecan <protein> An integral membrane proteoglycan (250-300 kD) associated largely with epithelial cells.
The core protein of 294 amino acids has an extracellular domain of 235 amino acids and a single transmembrane domain of 25 amino acids. The extracellular domain has up to three heparan sulphate and two chondroitin or dermatan sulphate chains plus an N linked oligosaccharide.
The heparan sulphate chains bind to several proteins of the extracellular matrix, including collagens, fibronectin and tenascin. The cytoplasmic domain is thought to interact with actin filaments. Its name is derived from the Greek syndein, to bind together.
(18 Nov 1997)
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  • Syndecan-1 - »õâ A syndecan that interacts with EXTRACELLULAR MATRIX PROTEINS and plays a role CELL PROLIFERATION and CELL MIGRATION.
    Synonyms : CD138 Antigen, Syndecan 1, Antigen, CD138
  • Syndecan-2 - »õâ A syndecan that is predominantly expressed during EMBRYONIC DEVELOPMENT. It may play a role in mediating cellular interactions with the EXTRACELLULAR MATRIX and may modulate the signaling activity of certain INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS.
    Synonyms : Fibroglycan, Heparan Sulfate Proteoglycan Core Protein, Syndecan 2
  • Syndecan-3 - »õâ A syndecan found at high levels in the developing LIMB BUD. It may play a role in the regulation of MUSCULOSKELETAL DEVELOPMENT by modulating the effects of INTERCELLULAR SIGNALING PROTEINS AND PEPTIDES.
    Synonyms : HB-GAM Receptor, Heparin-Binding Growth Associated Molecule Receptor, N-Syndecan, Syndecan 3, HB GAM Receptor, Heparin Binding Growth Associated Molecule Receptor, N Syndecan, Receptor, HB-GAM
  • Syndecan-4 - »õâ A ubiquitously expressed syndecan that is found in all stages of embryonic development and in most adult tissues. Syndecan-4 is found localized to focal adhesion sites in fibronectin-adherent cells and may play a role the process of CELL MIGRATION and CELL PROLIFERATION.
    Synonyms : Amphiglycan, Ryudocan, Ryudocan Core Protein, Syndecan 4, Syndecan4
  • Syndecans - »õâ A family of transmembrane glycoproteins that contain a short cytoplasmic domain, a single-span transmembrane domain, and an extracellular domain with HEPARIN SULFATE and CHONDROITIN SULFATE chains. Syndecans interact with a variety of heparin-binding INTERCELLULAR SIGNALING PROTEINS AND PEPTIDES and may play a role in modulating cellular signaling in during EMBRYONIC DEVELOPMENT, tumorigenesis, and angiogenesis.
    Synonyms : Syndecan
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