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  • JrId: 20299
    JournalTitle: Signature (Ramsey, N.J.)
    MedAbbr: Signature
    ISSN: 1091-5222
    ESSN:
    IsoAbbr:
    NlmId: 9609817
  • JrId: 22277
    JournalTitle: signal transduction knowledge environment.
    MedAbbr: Sci STKE
    ISSN:
    ESSN:
    IsoAbbr: Sci. STKE
    NlmId: 100964423
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CancerWEB ¿µ¿µ ÀÇÇлçÀü ¸ÂÃã °Ë»ö °á°ú : 15 ÆäÀÌÁö: 1
signal 1. Noticeable; distinguished from what is ordinary; eminent; remarkable; memorable; as, a signal exploit; a signal service; a signal act of benevolence. "As signal now in low, dejected state As erst in highest, behold him where he lies." (Milton)
2. Of or pertaining to signals, or the use of signals in conveying information; as, a signal flag or officer. The signal service, a bureau of the government (in the United States connected with the War Department) organised to collect from the whole country simultaneous raports of local meteorological conditions, upon comparison of which at the central office, predictions concerning the weather are telegraphed to various sections, where they are made known by signals publicly displayed. Signal station, the place where a signal is displayed; specifically, an observation office of the signal service.
Synonym: Eminent, remarkable, memorable, extraordinary, notable, conspicuous.
Origin: From signal, n., cf. F. Signale.
Source: Websters Dictionary
(01 Mar 1998)
signal detection (psychology) A theory of psychophysics which characterises not only the acuity of an individual's discrimination but also the psychological factors that bias his judgment.
(12 Dec 1998)
signal node A firm supraclavicular lymph node, especially on the left side, sufficiently enlarged that it is palpable from the cutaneous surface; such a lymph node is so termed because it may be the first recognised presumptive evidence of a malignant neoplasm in one of the viscera. A signal node that is known to contain a metastasis from a malignant neoplasm is sometimes designated by an old eponym, Troisier's ganglion.
Synonym: jugular gland, Virchow's node.
(05 Mar 2000)
signal peptidase A peptide present on proteins that are destined either to be secreted or to be membrane components. It is usually at the N terminus and normally absent from the mature protein. Normally refers to the sequence (ca 20 amino acids) that interacts with signal recognition particle and directs the ribosome to the endoplasmic reticulum where co translational insertion takes place. Could also refer to sequences that direct post translational uptake by organelles. Signal peptides are highly hydrophobic but with some positively charged residues. The signal sequence is normally removed from the growing peptide chain by signal peptidase, a specific protease located on the cisternal face of the endoplasmic reticulum.
See: signal recognition particle.
(18 Nov 1997)
signal peptidase complex A peptide present on proteins that are destined either to be secreted or to be membrane components. It is usually at the N terminus and normally absent from the mature protein. Normally refers to the sequence (ca 20 amino acids) that interacts with signal recognition particle and directs the ribosome to the endoplasmic reticulum where co translational insertion takes place. Could also refer to sequences that direct post translational uptake by organelles. Signal peptides are highly hydrophobic but with some positively charged residues. The signal sequence is normally removed from the growing peptide chain by signal peptidase, a specific protease located on the cisternal face of the endoplasmic reticulum.
See: signal recognition particle.
(18 Nov 1997)
signal peptide A peptide present on proteins that are destined either to be secreted or to be membrane components. It is usually at the N terminus and normally absent from the mature protein. Normally refers to the sequence (ca 20 amino acids) that interacts with signal recognition particle and directs the ribosome to the endoplasmic reticulum where co translational insertion takes place. Could also refer to sequences that direct post translational uptake by organelles. Signal peptides are highly hydrophobic but with some positively charged residues. The signal sequence is normally removed from the growing peptide chain by signal peptidase, a specific protease located on the cisternal face of the endoplasmic reticulum.
See: signal recognition particle.
(18 Nov 1997)
signal peptide p25-subunit IV cytochrome oxidase <chemical> Similar in action to melittin
Synonym: p25 presequence peptide-cytochrome oxidase, pre-ctox p25
(26 Jun 1999)
signal peptides Additional polypeptide sequence of 25 to 30 residues at the amino-terminal or carboxy-terminal end of proteins. The signal sequence signals the cellular fate or destination of a newly synthesised protein directing it to its ultimate destination in the cell. These leaders are recognised by the signal recognition particle and bound by specific receptor sites on the outer surface of the endoplasmic reticulum. They are then transported into the cisterna of the endoplasmic reticulum and from there directed to their ultimate destination in the cell. In prokaryotes, the signal peptides attach to the plasma membrane. These signal sequences are ultimately removed by specific peptidases.
(12 Dec 1998)
signal processing, computer-assisted Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.
(12 Dec 1998)
signal recognition particle A complex between a 7S RNA and six proteins. SRP binds to the nascent polypeptide chain of eukaryotic proteins with a signal sequence and halts further translation until the ribosome becomes associated with the rough endoplasmic reticulum. One of the SRP proteins (srp54) binds GTP and in association with 7SRNA and srp19 has GTPase activity.
(18 Nov 1997)
signal recognition particle receptor Receptor for the signal recognition particle (SRP) found in the membrane of the endoplasmic reticulum. Also called docking protein. Heterodimeric, both protomers having GTP binding capacity, though dissimilar binding sites. Not until the complex of SRP, ribosome, message and nascent polypeptide chain binds to the SRP receptor is the block to further chain elongation released and concurrently the SRP is released, leaving the ribosome attached to the endoplasmic reticulum membrane. Cotranslational transport of the polypeptide delivers it into the lumen of the ER.
(18 Nov 1997)
signal response coupling The cascade of processes by which an extracellular signal (typically a hormone or neurotransmitter) interacts with a receptor at the cell surface, causing a change in the level of a second messenger for example calcium or cyclic AMP) and ultimately effects a change in the cells functioning (for example: triggering glucose uptake or initiating cell division). Can also be applied to sensory signal transduction, for example of light at photoreceptors.
(18 Nov 1997)
signal sequence A peptide present on proteins that are destined either to be secreted or to be membrane components. It is usually at the N terminus and normally absent from the mature protein. Normally refers to the sequence (ca 20 amino acids) that interacts with signal recognition particle and directs the ribosome to the endoplasmic reticulum where co translational insertion takes place. Could also refer to sequences that direct post translational uptake by organelles. Signal peptides are highly hydrophobic but with some positively charged residues. The signal sequence is normally removed from the growing peptide chain by signal peptidase, a specific protease located on the cisternal face of the endoplasmic reticulum.
See: signal recognition particle.
(18 Nov 1997)
signal transduction The cascade of processes by which an extracellular signal (typically a hormone or neurotransmitter) interacts with a receptor at the cell surface, causing a change in the level of a second messenger for example calcium or cyclic AMP) and ultimately effects a change in the cells functioning (for example: triggering glucose uptake or initiating cell division). Can also be applied to sensory signal transduction, for example of light at photoreceptors.
(18 Nov 1997)
signal void In magnetic resonance imaging, a region emitting no radiofrequency signal, either because there are no activated protons in the region (such as flowing blood) or because a different element predominates, particularly calcium.
(05 Mar 2000)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 4 ÆäÀÌÁö: 1
  • Signal Detection (Psychology) - »õâ Psychophysical technique that permits the estimation of the bias of the observer as well as detectability of the signal (i.e., stimulus) in any sensory modality. (From APA, Thesaurus of Psychological Index Terms, 8th ed.)
    Synonyms : Signal Detection Analysis, Signal Detection Theory, Analyses, Signal Detection, Analysis, Signal Detection, Detection, Signal (Psychology), Detections, Signal (Psychology), Signal Detection Analyses, Signal Detection Theories, Signal Detections (Psychology)
  • Signal Processing, Computer-Assisted - »õâ Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.
    Synonyms : Computer-Assisted Signal Interpretation, Computer-Assisted Signal Interpretations, Computer-Assisted Signal Processing, Interpretation, Computer-Assisted Signal, Interpretations, Computer-Assisted Signal, Signal Interpretation, Computer Assisted
  • Signal Recognition Particle - »õâ A cytosolic ribonucleoprotein complex that acts to induce elongation arrest of nascent presecretory and membrane proteins until the ribosome becomes associated with the rough endoplasmic reticulum. It consists of a 7S RNA and at least six polypeptide subunits (relative molecular masses 9, 14, 19, 54, 68, and 72K).
    Synonyms : Particle, Signal Recognition, Recognition Particle, Signal
  • Signal Transduction - »õâ The intercellular or intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
    Synonyms : Receptor Mediated Signal Transduction, Signal Transduction Pathways, Signal Transduction Systems, Pathway, Signal, Pathway, Signal Transduction, Pathways, Signal, Pathways, Signal Transduction, Receptor-Mediated Signal Transductions, Signal Pathway
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signal any communication that encodes a message; "signals from the boat suddenly stopped" sign: communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" any incitement to action; "he awaited the signal to start"; "the victory was a signal for wild celebration" notably out of the ordinary; "the year saw one signal triumph for the Labour party" bespeak: be a signal for or a symptom of; "These symptoms indicate a serious illness"; "Her behavior points to a severe neurosis"; "The economic indicators signal that the euro is undervalued" an electric quantity (voltage or current or field strength) whose modulation represents coded information about the source from which it comes
Ãâó: wordnet.princeton.edu/perl/webwn
signature your name written in your own handwriting touch: a distinguishing style; "this room needs a woman's touch" a melody used to identify a performer or a dance band or radio/tv program key signature: the sharps or flats that follow the clef and indicate the key a sheet with several pages printed on it; it folds to page size and is bound with other signatures to form a book
Ãâó: wordnet.princeton.edu/perl/webwn
signal-to-noise ratio the ratio of signal intensity to noise intensity
Ãâó: wordnet.princeton.edu/perl/webwn
signal sequence a sequence of 15 to 30 amino acids occurring at the N-terminal of the precursors of secretory proteins; it is required for transport of the protein across the membrane of the rough endoplasmic reticulum into the cisternae, where it is immediately cleaved off by an endopeptidase. Called also leader s. and signal peptide.
Ãâó: www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspz...
signature In mathematics, the permutations of a finite set (i.e. the bijective maps from the set to itself) fall into two equal classes: the even permutations and the odd permutations. An even permutation is one that can be produced by an even number of exchanges of two elements (these exchanges are called transpositions). An odd permutation is one that can be produced by an odd number of transpositions. ...
Ãâó: en.wikipedia.org/wiki/Signature_(permutation)
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signa signs collectively (especially commercial signs or posters
signa any communication that encodes a message
signa any incitement to action
signa an electric quantity (voltage or current or field strength) whose modulation represents coded information about the source from which it comes
signa be a signal for or a symptom of
signa communicate silently and non-verbally by signals or signs
signa notably out of the ordinary
signa a building from which signals are sent to control the movements of railway trains
signa the position of the football player in the backfield who directs the offensive play of his team
signa (football) the person who plays quarterback
signa the detection that a signal is being received
signa a fire set as a signal
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