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IFN InterFeroN
INF-¥ã Interferon-¥ã
FIF feedback inhibition factor; fibroblast interferon; forced inspiratory flow; formaldehyde-induced flu...
HFI hereditary fructose intolerance; human fibroblast interferon
HFIF human fibroblast interferon
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IFN 1-interferon
IF 2-interferon
IFN alpha Alpha interferon
alpha IFN Alpha interferon
IFN Alpha-2-interferon
CancerWEB ¿µ¿µ ÀÇÇлçÀü ¸ÂÃã °Ë»ö °á°ú : 6 ÆäÀÌÁö: 1
interferon-alpha <cytokine> One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells when exposed to live or inactivated virus, double-stranded RNA, or bacterial products.
It is the major interferon produced by virus-induced leukocyte cultures and, in addition to its pronounced antiviral activity, causes activation of NK cells. It is used experimentally in the treatment of hairy-cell leukaemia.
A number of different subtypes exist that are elaborated by leukocytes in response to viral infection or stimulation with double-stranded RNA; IFN-alpha-2A and -2B are protein products made by recombinant DNA techniques and are used as antineoplastic agents.
See: interferon-alpha 2a, interferon-alpha 2b
Synonym: leukocyte interferon.
Pharmacological action: antineoplastic agent, antiviral agent.
(20 Sep 2002)
interferon-alpha 2a <cytokine> Interferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.
Pharmacological action: antineoplastic agent, antiviral agents.
Chemical name: Interferon-alphaA (human leukocyte protein moiety reduced)
(12 Dec 1998)
interferon-alpha 2b <chemical> Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.
Pharmacological action: antineoplastic agent, antiviral agents.
(12 Dec 1998)
interferon-b2 <cytokine> A cytokine that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas.
It is produced by many different cells including T-cells, monocytes, and fibroblasts. A single chain 25 kD cytokine originally described as a pre B-cell growth factor, now known to have effects on a number of other cells including T-cells which are also stimulated to proliferate.
An inducer of acute phase proteins and a colony-stimulating factor acting on mouse bone marrow.
Acronym: IL-6
(12 Dec 1998)
interferon-beta <cytokine> One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.
Synonym: fibroblast interferon.
Pharmacological action: adjuvants, immunologic, antineoplastic agent, antiviral agents.
Chemical name: Interferon-alphaB (human leukocyte protein moiety reduced)
(12 Dec 1998)
interferon-gamma <cytokine> Interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation.
This type II interferon can be produced by recombinant DNA technology and is similar to the interferon secreted by lymphocytes and has antiviral and antineoplastic activity.
Synonym: antigen interferon, immune interferon.
Pharmacological action: antineoplastic agent, antiviral agents.
(20 Sep 2002)
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alpha interferon <cytokine> Interferon which is released by leukocytes in response to a viral infection. A protein cytokine that is used as an anticancer agent.
(15 Nov 1997)
antigen interferon <cytokine> Interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation.
This type II interferon can be produced by recombinant DNA technology and is similar to the interferon secreted by lymphocytes and has antiviral and antineoplastic activity.
Synonym: antigen interferon, immune interferon.
Pharmacological action: antineoplastic agent, antiviral agents.
(20 Sep 2002)
beta interferon A protein liberated by fibroblasts in response to a viral infection.
(27 Sep 1997)
receptors, interferon Specific molecular sites or structures on or in cells with which interferons react or to which they bind in order to modify the function of the cells. Interferons exert their pleiotropic effects through two different receptors. Alpha- and beta-interferon crossreact with common receptors, while gamma-interferon initiates its biological effects through its own specific receptor system.
(12 Dec 1998)
immune interferon <cytokine> Interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation.
This type II interferon can be produced by recombinant DNA technology and is similar to the interferon secreted by lymphocytes and has antiviral and antineoplastic activity.
Synonym: antigen interferon, immune interferon.
Pharmacological action: antineoplastic agent, antiviral agents.
(20 Sep 2002)
interferon <cytokine> A family of glycoproteins derived from human cells which normally has a role in fighting viral infections by preventing virus multiplication in cells.
They are secreted by vertebrate cells in response to a wide variety of inducers and confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
Interferon-alpha is made by leucocytes and interferon-gamma by fibroblasts after viral infection. Interferon-alpha and -beta are also called type I interferons, interferon-gamma as Type II interferons, more usually classed as cytokines.
Pharmacological action: antineoplastic agent, antiviral agents.
(20 Sep 2002)
interferon inducers Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers poly a-u and poly I-c. Viruses, bacteria, and protozoa have been also known to induce interferons.
(12 Dec 1998)
interferon type I <chemical> Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (interferon-alpha and interferon-beta).
Pharmacological action: antineoplastic agent, antiviral agents.
(12 Dec 1998)
interferon type II <chemical> The major interferon produced by mitogenically or antigenically stimulated lymphocytes. It is structurally different from type I interferon (interferon type I) and its major activity is immunoregulation. It has been implicated in the expression of class II histocompatibility antigens in cells that do not normally produce them, leading to autoimmune disease.
Pharmacological action: antineoplastic agent, antiviral agents.
Chemical name: Interferon-gamma (human lymphocyte protein moiety reduced)
(12 Dec 1998)
type II interferon <chemical> The major interferon produced by mitogenically or antigenically stimulated lymphocytes. It is structurally different from type I interferon (interferon type I) and its major activity is immunoregulation. It has been implicated in the expression of class II histocompatibility antigens in cells that do not normally produce them, leading to autoimmune disease.
Pharmacological action: antineoplastic agent, antiviral agents.
Chemical name: Interferon-gamma (human lymphocyte protein moiety reduced)
(12 Dec 1998)
type I interferon <chemical> Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (interferon-alpha and interferon-beta).
Pharmacological action: antineoplastic agent, antiviral agents.
(12 Dec 1998)
fibroblast interferon <cytokine> One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.
Synonym: fibroblast interferon.
Pharmacological action: adjuvants, immunologic, antineoplastic agent, antiviral agents.
Chemical name: Interferon-alphaB (human leukocyte protein moiety reduced)
(12 Dec 1998)
leukocyte interferon <cytokine> One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells when exposed to live or inactivated virus, double-stranded RNA, or bacterial products.
It is the major interferon produced by virus-induced leukocyte cultures and, in addition to its pronounced antiviral activity, causes activation of NK cells. It is used experimentally in the treatment of hairy-cell leukaemia.
A number of different subtypes exist that are elaborated by leukocytes in response to viral infection or stimulation with double-stranded RNA; IFN-alpha-2A and -2B are protein products made by recombinant DNA techniques and are used as antineoplastic agents.
See: interferon-alpha 2a, interferon-alpha 2b
Synonym: leukocyte interferon.
Pharmacological action: antineoplastic agent, antiviral agent.
(20 Sep 2002)
MeSH(Medical Subject Headings) ¸ÂÃã °Ë»ö (http://www.nlm.nih.gov) °á°ú : 5 ÆäÀÌÁö: 1
  • Interferon-alpha - »õâ One of the type I interferons (INTERFERON TYPE I) produced by peripheral blood leukocytes or lymphoblastoid cells when exposed to live or inactivated virus, double-stranded RNA, or bacterial products. It is the major interferon produced by virus-induced leukocyte cultures and, in addition to its pronounced antiviral activity, it causes activation of NK cells.
    Synonyms : Interferon Alfa-n1, Interferon Alfa-n3, Interferon, Lymphoblastoid, Interferon, alpha, Wellferon, Interferon Alfa n1, Interferon Alfa n3, Interferon alpha, Leukocyte Interferon, Lymphoblast Interferon, Lymphoblastoid Interferon, alpha Interferon
  • Interferon-beta - »õâ One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.
    Synonyms : Fiblaferon, Interferon, beta, Interferon, beta-1, Interferon-beta1, beta-1 Interferon, Fibroblast Interferon, Interferon beta, Interferon beta1, Interferon, beta 1, beta 1 Interferon, beta Interferon
  • Interferon-gamma, Recombinant - »õâ A type II interferon produced by recombinant DNA technology. It is similar to the interferon secreted by lymphocytes and has antiviral and antineoplastic activity.
    Synonyms : Recombinant gamma Interferon, Type II Interferon, Recombinant, Interferon gamma 1b, Interferon gamma 2a, Interferon gamma, Recombinant, Interferon, Recombinant gamma, Recombinant Interferon gamma, Recombinant gamma-Interferon, gamma Interferon, Recombinant
  • Interferon-Stimulated Gene Factor 3 - »õâ A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.
    Synonyms : ISGF3 Factor, Transcription Factor ISGF3, IFN Stimulated Gene Factor 3 Complex, ISGF3, Transcription Factor, Interferon Stimulated Gene Factor 3, Transcription Factor, ISGF3
  • Interferon-Stimulated Gene Factor 3, alpha Subunit - »õâ A heterodimeric complex of STAT1 PROTEIN and STAT2 PROTEIN that interacts with ISGF3GAMMA and is a subunit of the ISGF3 COMPLEX.
    Synonyms : ISGF3 alpha Subunit, ISGF3-alpha Protein, ISGF3 alpha Protein, Interferon Stimulated Gene Factor 3, alpha Subunit
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