| 6-phosphofructo-2-kinase | <enzyme> Copurifies with fructose-2,6-bisphosphatase; probably is a single protein with both activities Registry number: EC 2.7.1.105 Synonym: ATP-d-fructose-6-phosphate 2-phosphotransferase, fructose-6-phosphate,2-kinase, fructose-6-p,2-kinase, fru-6-p,2-kinase, 6pf2k (26 Jun 1999) |
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| 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase | <chemical> Hepatic bifunctional enzyme that both degrades and synthesises fructose-2,6-bisphosphate Synonym: 6pf-2-k-fru-2,6-p(2)ase, hepatic 6-phosphofructo-2-kinase, hepatic fructose-2,6-bisphosphatase, pfk-2 (liver), pbpase-2 (liver) (26 Jun 1999) |
| 6-phosphofructo-2-kinase |
[EC 2.7.1.105] an enzyme activity that catalyzes the phosphorylation of fructose 6-phosphate by ATP to form fructose 2,6-bisphosphate; it occurs on the same polypeptide as the enzyme activity fructose-2,6-bisphosphate 2-phosphatase (q.v.). In liver, the two activities form part of a mechanism for regulating carbohydrate metabolism. The liver enzyme activity is inhibited via phosphorylation by cyclic-AMPdependent protein kinase, thus diminishing the rate of formation of fructose 2,6-bisphosphate and slowing glycolysis. Called also phosphofructokinase 2.
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