| 6-phosphofructokinase | <enzyme> An enzyme that catalyses the conversion of a nucleotide triphosphate and a sugar phosphate to a nucleotide diphosphate and a sugar diphosphate. D-fructose 6-phosphate, d-tagatose 6-phosphate, and sedoheptulose 7-phosphate can act as acceptors; ATP, utp, ctp, and itp can act as donors. A deficiency of this enzyme is the cause of glycogen storage disease type vii. Chemical name: ATP:D-fructose-6-phosphate 6-phosphotransferase Registry number: EC 2.7.1.11 (12 Dec 1998) |
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| 6-phosphofructokinase |
[EC 2.7.1.11] an enzyme of the transferase class that catalyzes the phosphorylation of fructose 6-phosphate by ATP to form fructose 1,6-bisphosphate. The reaction is essentially irreversible and is a committed step and a key site of regulation in the Embden-Meyerhof pathway of glucose metabolism. Numerous isozymes occur; deficiency of the muscle isoenzyme, an autosomal recessive trait, is the cause of glycogen storage disease, type VII. Called also phosphofructokinase 1.
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