단순히 복약법이나 흔한 부작용 등 지식을 얻고 싶으시면 www.drugs.com여기 가시고요
더 자세하고 전문적인 내용을 원하시면 physician's desk reference (PDR)을 보시는 것이 나은데, 아마 유료일 겁니다. 도서관에 단행본으로 있을 수는 있어요.
저는 간편한 무료 사이트로 drugbank.ca 이 사이트를 자주 찾습니다.
자세한 약리 기전을 이해하고 싶으시다면 교과서를 차라리 추천드리고요
vancomycin이면 안 다루는 약리학 책이 없으니 도서관에서 아무 약리학 책이나 골라 보세요. 제가 본 책 중에서는
Lippincott's illustrated reviews: pharmacology < Basic and Clinical Pharmacology (Katzung) < Goodman and Gilman's Pharmacological Basis of Therapeutics
이 순으로 자세하고요, 웬만한 대학교 및 의대 도서관에는 다 있을 겁니다.
2011.04.02 16:41:38
Oscar
작용 원리에 대한 간단하고 개략적인 이해에는 짧지만 이 사이트도 도움이 됩니다.
Vancomycin mechanism of action: an animation. from Pharmacology Corner: http://pharmacologycorner.com/vancomycin-mechanism-action-animation/
2011.04.02 16:41:38
Oscar
기본적으로 박테리아가 세포벽을 유지하지 못하게 하는게 반코마이신의 작용원리입니다. 아래는 제가 이번에 숙제로 제출한 내용인데 뭐 썩 잘 쓴글은 아닙니다만 읽어보시고 이해해 약간이나마 도움 되었으면 합니다...
Bacteria have a rigid outer layer, which called the cell wall. It helps bacteria to maintain its shape and size, and acts as a barrier against cell lysis caused by difference in tonicity. If bacteria fail to maintain its cell wall, the fluids from the environment flow into the cell and will lyse it. Thus, if we administer drugs that inhibit bacteria cell synthesis, we can effectively kill them. For Gram positive bacteria, the outermost layer is composed of peptidoglycan, which formed by weaving N-acetylglucosamine and N-acetylmuramic acid into a basket-like structure. Individual peptidoglycan molecule is connected together by cross-linking activity of transpeptidase enzymes, which forms a peptide bridge between short peptide side chains (NAM) that branched out from the long glycan molecules. This is the mechanism that fortifies the interconnection between peptidoglycan and consequently, the cell wall. This cross-linking process is the principle target of two of the most important groups of antimicrobics; β-lactams and the glycopeptides (vancomycin and teicoplanin). Vancomycin, along with teicoplanin, belongs to glycopeptides antimicrobics. This family of antimicrobics binds to the pentapeptides of the peptidoglycan monomers, especially by making complex with the D-alanyl-D-alanine moieties, preventing them from establishing linkage between neighboring peptidoglycan monomer by the transpeptidase enzyme
In the bacteria, there is a special enzyme called autolysin that digests the cell-wall peptidoglycan of the bacteria, by breaking the peptide cross-link. It can be found universally among bacteria which have peptidoglycan wall. It might sound weird that bacteria have enzyme that digest their own cell wall, but autolysin “selectively” digests peptidoglycan and its reaction is very crucial for numerous cellular processes, such as cell growth, cell wall turnover, peptidoglycan maturation, cell division and separation.
In vancomycin cell wall synthesis inhibition, the autolysin continue to break the peptide cross-link for normal bacterial cellular function, but the formation of new links are blocked by vancomycin. Vancomycin attaches to the pentapeptides of peptidoglycan monomer, preventing transpeptidase enzyme from making cross-linkage between them. As a result, bacteria lost the integrity of the cell wall and the parts of the cell wall begin to fall apart. Finally, it is lysed by osmotic pressure. Vancomycin is only effective against Gram-positive bacteria, such as Staphylococcus aureus and Staphylococcus epidermidis. Gram negative bacteria, which have LPS (lipopolysaccharides) as outermost membrane and more complicated cell wall structure that inhibits entry of antibiotics, are not susceptible to vancomycin.
2011.04.02 16:41:38
Oscar
Hammes, W., & Neuhaus, F. (1974). On the Mechanism of Action of Vancomycin: Inhibition: of Peptidoglycan Synthesis in Gaffkya homari. Antimicrobial agents and chemotherapy, 6(6), 722-728.
구글링해보세요. 무료 링크가 있었는지 없었는지는 기억이 잘 안납니다...
단순히 복약법이나 흔한 부작용 등 지식을 얻고 싶으시면 www.drugs.com여기 가시고요
더 자세하고 전문적인 내용을 원하시면 physician's desk reference (PDR)을 보시는 것이 나은데, 아마 유료일 겁니다. 도서관에 단행본으로 있을 수는 있어요.
저는 간편한 무료 사이트로 drugbank.ca 이 사이트를 자주 찾습니다.
자세한 약리 기전을 이해하고 싶으시다면 교과서를 차라리 추천드리고요
vancomycin이면 안 다루는 약리학 책이 없으니 도서관에서 아무 약리학 책이나 골라 보세요. 제가 본 책 중에서는
Lippincott's illustrated reviews: pharmacology < Basic and Clinical Pharmacology (Katzung) < Goodman and Gilman's Pharmacological Basis of Therapeutics
이 순으로 자세하고요, 웬만한 대학교 및 의대 도서관에는 다 있을 겁니다.
Vancomycin mechanism of action: an animation. from Pharmacology Corner: http://pharmacologycorner.com/vancomycin-mechanism-action-animation/
Bacteria have a rigid outer layer, which called the cell wall. It helps bacteria to maintain its shape and size, and acts as a barrier against cell lysis caused by difference in tonicity. If bacteria fail to maintain its cell wall, the fluids from the environment flow into the cell and will lyse it. Thus, if we administer drugs that inhibit bacteria cell synthesis, we can effectively kill them. For Gram positive bacteria, the outermost layer is composed of peptidoglycan, which formed by weaving N-acetylglucosamine and N-acetylmuramic acid into a basket-like structure. Individual peptidoglycan molecule is connected together by cross-linking activity of transpeptidase enzymes, which forms a peptide bridge between short peptide side chains (NAM) that branched out from the long glycan molecules. This is the mechanism that fortifies the interconnection between peptidoglycan and consequently, the cell wall. This cross-linking process is the principle target of two of the most important groups of antimicrobics; β-lactams and the glycopeptides (vancomycin and teicoplanin). Vancomycin, along with teicoplanin, belongs to glycopeptides antimicrobics. This family of antimicrobics binds to the pentapeptides of the peptidoglycan monomers, especially by making complex with the D-alanyl-D-alanine moieties, preventing them from establishing linkage between neighboring peptidoglycan monomer by the transpeptidase enzyme
In the bacteria, there is a special enzyme called autolysin that digests the cell-wall peptidoglycan of the bacteria, by breaking the peptide cross-link. It can be found universally among bacteria which have peptidoglycan wall. It might sound weird that bacteria have enzyme that digest their own cell wall, but autolysin “selectively” digests peptidoglycan and its reaction is very crucial for numerous cellular processes, such as cell growth, cell wall turnover, peptidoglycan maturation, cell division and separation.
In vancomycin cell wall synthesis inhibition, the autolysin continue to break the peptide cross-link for normal bacterial cellular function, but the formation of new links are blocked by vancomycin. Vancomycin attaches to the pentapeptides of peptidoglycan monomer, preventing transpeptidase enzyme from making cross-linkage between them. As a result, bacteria lost the integrity of the cell wall and the parts of the cell wall begin to fall apart. Finally, it is lysed by osmotic pressure. Vancomycin is only effective against Gram-positive bacteria, such as Staphylococcus aureus and Staphylococcus epidermidis. Gram negative bacteria, which have LPS (lipopolysaccharides) as outermost membrane and more complicated cell wall structure that inhibits entry of antibiotics, are not susceptible to vancomycin.
구글링해보세요. 무료 링크가 있었는지 없었는지는 기억이 잘 안납니다...