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분홍토끼
2005.07.29 14:09
안녕하세요.
아래 링크를 참고하시길 바랍니다.
Intrinsic sympathomimetic activity :
Some beta-blockers, such as pindolol and acebutolol, also have beta-agonist properties. While their agonist property is weaker than that of catecholamines, they are capable of stimulating beta-receptors, especially when catecholamine levels are low. These agents are said to have intrinsic sympathomimetic activity; this agonist property is protective in overdoses

Membrane stabilizing effects :
Beta-blockers, such as propranolol, labetalol, and pindolol, can have membrane stabilizing effects (eg, quinidinelike effects, Vaughan-Williams class I antiarrhythmic effects). This property, usually not evident with therapeutic doses, may significantly contribute to toxicity by prolonging QRS duration and impairing cardiac conduction. Seizures are more commonly observed in the drugs with quinidinelike membrane stabilizing effects.

참고 링크:
http://www.emedicine.com/emerg/topic59.htm (영문/무료 가입 필요)

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