Nephroprotective agent
Oral acetylcysteine is used for the prevention of radiocontrast-induced nephropathy (a form of acute renal failure). Some studies show that prior administration of acetylcysteine markedly decreases (90%) radiocontrast nephropathy (Tepel et al 2000), whereas others appear to cast doubt on its efficacy (Hoffman et al., 2004; Miner et al., 2004). Worth considering is the newest data published in two papers in the New England Journal of Medicine and the Journal of the American Medical Association. The authors' conclusions in those papers were: 1) "Intravenous and oral N-acetylcysteine may prevent contrast-medium–induced nephropathy with a dose-dependent effect in patients treated with primary angioplasty and may improve hospital outcome." (Marenzi et al, 2006) 2) "Acetylcysteine protects patients with moderate chronic renal insufficiency from contrast-induced deterioration in renal function after coronary angiographic procedures, with minimal adverse effects and at a low cost" (Kay et al., 2003).
Acetylcysteine continues to be commonly used in individuals with renal impairment to prevent the precipitation of acute renal failure.
- wikipedia에서 찾은 내용..
저도 예전에 acetylcysteine을 nebulizer, mucolytic agent로 사용하면서
조영제 주기 전에 주는 것이 궁금하여 찾아보았던 내용 중 일부입니다.
acetylcysteine이 확실히는 모르겠지만 단백질을 조각(?)내주는 작용이 있다고
본 기억이... 있습니다.
아마도 acetylcysteine을 주면서 hydration도 같이 하겠지요.
2009.05.04 11:24:45
sseojia
acetylcystein이 cr감소에 영향을 미친다고 알려져 있습니다.(기전은 아직..)
그래서 enhance 촬영시 주로 줍니다.
2009.05.04 11:24:45
slothgw
N-acetylcystein은 항산화제 역할을 한다고 알고 있어요~
Contrast induced ARF는 ROS 발생과 관련이 있구요 ㅎ
Oral acetylcysteine is used for the prevention of radiocontrast-induced nephropathy (a form of acute renal failure). Some studies show that prior administration of acetylcysteine markedly decreases (90%) radiocontrast nephropathy (Tepel et al 2000), whereas others appear to cast doubt on its efficacy (Hoffman et al., 2004; Miner et al., 2004). Worth considering is the newest data published in two papers in the New England Journal of Medicine and the Journal of the American Medical Association. The authors' conclusions in those papers were: 1) "Intravenous and oral N-acetylcysteine may prevent contrast-medium–induced nephropathy with a dose-dependent effect in patients treated with primary angioplasty and may improve hospital outcome." (Marenzi et al, 2006) 2) "Acetylcysteine protects patients with moderate chronic renal insufficiency from contrast-induced deterioration in renal function after coronary angiographic procedures, with minimal adverse effects and at a low cost" (Kay et al., 2003).
Acetylcysteine continues to be commonly used in individuals with renal impairment to prevent the precipitation of acute renal failure.
- wikipedia에서 찾은 내용..
저도 예전에 acetylcysteine을 nebulizer, mucolytic agent로 사용하면서
조영제 주기 전에 주는 것이 궁금하여 찾아보았던 내용 중 일부입니다.
acetylcysteine이 확실히는 모르겠지만 단백질을 조각(?)내주는 작용이 있다고
본 기억이... 있습니다.
아마도 acetylcysteine을 주면서 hydration도 같이 하겠지요.
그래서 enhance 촬영시 주로 줍니다.
Contrast induced ARF는 ROS 발생과 관련이 있구요 ㅎ