췌장의 베타 세포 -_-;
더 자세한 기능 등은 내과, 생리학, 조직학, 백과사전, 일반 웹 검색 등 다양한 곳에서 쉽게 찾을 수 있습니다.
--------------------------------------------------------------------------------------
항상 말하듯이 본인은 답변의 정확성 및 내용에 대한 아무런 책임을 지지 않으며, 참고사항으로 답변을 제공합니다.
2005.06.06 14:05:03
유지명
재생불능성빈혈의 원인에 대해 알고싶습니다.
각 원인이 차지하는 비율을 대략이라도 알고 싶습니다.
2005.06.06 14:05:03
분홍토끼
내과 책을 직접 찾아보시길 것이 가장 정확할 것입니다.
Congenital/inherited (20%)
Patients usually have dysmorphic features or physical stigmata. Occasionally, marrow failure may be the initial presenting feature.
Fanconi anemia
Dyskeratosis congenita
Cartilage hair hypoplasia
Pearson syndrome
Amegakaryocytic thrombocytopenia (thrombocytopenia-absent radius [TAR] syndrome)
Shwachman-Diamond syndrome
Dubowitz syndrome
Diamond-Blackfan syndrome
Familial aplastic anemia
Acquired (80%)
Idiopathic
Infectious causes such as hepatitis viruses, Ebstein-Barr virus (EBV), HIV, parvovirus, and mycobacterial infections
Toxic exposure to radiation and chemicals such as benzene
Drugs, such as chloramphenicol, phenylbutazone, and gold, may cause aplasia of the marrow. The immune mechanism does not explain the marrow failure in idiosyncratic drug reactions. In such cases, direct toxicity may occur, perhaps due to genetically determined differences in metabolic detoxification pathways; for example, the null phenotype of certain glutathione transferases is over-represented among patients with aplastic anemia.
PNH is caused by an acquired genetic defect limited to the stem cell compartment affecting the PIGA gene. The PIGA gene mutations render cells of hematopoietic origin sensitive to increased complement lysis. Approximately 20% of patients with aplastic anemia have evidence of PNH at presentation as detected by flow cytometry. Furthermore, patients who respond following immunosuppressive therapy frequently recover with clonal hematopiesis and PNH.
Transfusional graft versus host disease
Orthotopic liver transplantation for fulminant hepatitis
Pregnancy
Eosinophilic fascitis
참고 링크: http://www.emedicine.com/med/topic162.htm
--------------------------------------------------------------------------------------
항상 말하듯이 본인은 답변의 정확성 및 내용에 대한 아무런 책임을 지지 않으며, 참고사항으로 답변을 제공합니다.
더 자세한 기능 등은 내과, 생리학, 조직학, 백과사전, 일반 웹 검색 등 다양한 곳에서 쉽게 찾을 수 있습니다.
--------------------------------------------------------------------------------------
항상 말하듯이 본인은 답변의 정확성 및 내용에 대한 아무런 책임을 지지 않으며, 참고사항으로 답변을 제공합니다.
각 원인이 차지하는 비율을 대략이라도 알고 싶습니다.
Congenital/inherited (20%)
Patients usually have dysmorphic features or physical stigmata. Occasionally, marrow failure may be the initial presenting feature.
Fanconi anemia
Dyskeratosis congenita
Cartilage hair hypoplasia
Pearson syndrome
Amegakaryocytic thrombocytopenia (thrombocytopenia-absent radius [TAR] syndrome)
Shwachman-Diamond syndrome
Dubowitz syndrome
Diamond-Blackfan syndrome
Familial aplastic anemia
Acquired (80%)
Idiopathic
Infectious causes such as hepatitis viruses, Ebstein-Barr virus (EBV), HIV, parvovirus, and mycobacterial infections
Toxic exposure to radiation and chemicals such as benzene
Drugs, such as chloramphenicol, phenylbutazone, and gold, may cause aplasia of the marrow. The immune mechanism does not explain the marrow failure in idiosyncratic drug reactions. In such cases, direct toxicity may occur, perhaps due to genetically determined differences in metabolic detoxification pathways; for example, the null phenotype of certain glutathione transferases is over-represented among patients with aplastic anemia.
PNH is caused by an acquired genetic defect limited to the stem cell compartment affecting the PIGA gene. The PIGA gene mutations render cells of hematopoietic origin sensitive to increased complement lysis. Approximately 20% of patients with aplastic anemia have evidence of PNH at presentation as detected by flow cytometry. Furthermore, patients who respond following immunosuppressive therapy frequently recover with clonal hematopiesis and PNH.
Transfusional graft versus host disease
Orthotopic liver transplantation for fulminant hepatitis
Pregnancy
Eosinophilic fascitis
참고 링크: http://www.emedicine.com/med/topic162.htm
--------------------------------------------------------------------------------------
항상 말하듯이 본인은 답변의 정확성 및 내용에 대한 아무런 책임을 지지 않으며, 참고사항으로 답변을 제공합니다.