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GI motility ´ëÀå°æ Á¤¸®

1. MMC(migrating motor complex): °øº¹½Ã »óºÎÀ§Àå°ü¿¡¼­ ¼ÒÀå¿¡ °ÉÃļ­ À̵¿µÇ´Â

ÁÖ±âÀûÀÎ Àü±âȰµ¿¾ç»ó

2. À§Àå°üÀÇ ¿©·¯ºÎÀ§¿¡ Á¸ÀçÇÏ¸ç ¿îµ¿À» Á¶ÀýÇÏ´Â pacemaker·Î¼­ spontaneously active

cell·Î ÀÛ¿ëÇÏ´Â ¼¼Æ÷ÀÇ À̸§Àº? Interstitial cell of Cajal

* ÀÌ ¼¼Æ÷ÀÇ Á¸À縦 ¾Ë°Ô ÇØ ÁÖ´Â À¯ÀüÀڷμ­ tyrosine kinase receptor¸¦ codeÇÏ´Â

proto-oncogeneÀÇ À̸§Àº? proto-oncogene c-kit

3. enteric nervous systemÀº Àå¿îµ¿ÀÇ Á¶ÀýÀ» À§ÇØ ¼ö¸¹Àº »óÈ£ ¿¬°áÀ» °¡Áö°í ÀÖ´Ù.

¿©±â¿¡ °ü¿©ÇÏ´Â brain stem³»ÀÇ nucleus 2°¡Áö À̸§?

NTS(nucleus tractus solitarius), DMN(dorsal motor nucleus)

* À̵鿡°Ô¼­ inputÀ» ¹Þ´Â afferent neuronÀÇ ½Å°æÀýÀÇ À̸§? prevertebrate ganglia

4. À§Àå°ü ¿îµ¿¼ºÀ» ÀÚ±ØÇϴ ȣ¸£¸ó(ACTING)

Acetylcholine, CCK, 5-hydroxytryptamine, Neurokinin, Gastrin-releasing peptide

5. À§Àå°ü ¿îµ¿¼ºÀ» ¾ïÁ¦Çϴ ȣ¸£¸ó(³ëºêÄ® NP)

NO, VIP, Calcitonin gene-related peptide, Neuropeptide Y, peptide YY, ATP

enteroglucagon

6. À§Àå°ü ¿îµ¿¼º ÀÚ±Ø & ¾ïÁ¦ µÑ´Ù ÀÛ¿ë(NES): neurotensin, enkephalin, somatostatin

7. rapid gastric emptying

dumping syndrome, pancreatic insufficiency, celiac sprue, Zollinger-Ellison syndrome

duodenal ulcer

8. delayed gastric emptying

postvagotomy, DM, viral infecion, reflux esophagitis, brain stem lesions, anorexia

nervosa, tachygastria, systemic sclerosis

9. functional dyspepsiaÀÇ Rome II classification¿¡ µû¸¥ 3 subtypes

: ulcer type, dysmotility type, unspecified type

10. systemic sclerosisȯÀÚ¿¡¼­ ³ªÅ¸³ª´Â motility disorder Áõ»ó¿ÏÈ­¿¡ µµ¿òÀ» ÁÙ¼ö ÀÖ´Â

¾àÁ¦¿Í ÀÛ¿ë±âÀü?

¾àÁ¦: octreotide *±âÀü: MMCÀÇ phase 3¸¦ stimulation

11. chronic intestinal pseudoobstructionÀ» ÀÏÀ¸Å°´Â ´ëÇ¥Àû ³»ºÐºñÁúȯ 2°¡Áö?

DM, hypothyroidism