GI motility ´ëÀå°æ Á¤¸®
1. MMC(migrating motor complex): °øº¹½Ã »óºÎÀ§Àå°ü¿¡¼ ¼ÒÀå¿¡ °ÉÃļ À̵¿µÇ´Â
ÁÖ±âÀûÀÎ Àü±âȰµ¿¾ç»ó
2. À§Àå°üÀÇ ¿©·¯ºÎÀ§¿¡ Á¸ÀçÇÏ¸ç ¿îµ¿À» Á¶ÀýÇÏ´Â pacemaker·Î¼ spontaneously active
cell·Î ÀÛ¿ëÇÏ´Â ¼¼Æ÷ÀÇ À̸§Àº? Interstitial cell of Cajal
* ÀÌ ¼¼Æ÷ÀÇ Á¸À縦 ¾Ë°Ô ÇØ ÁÖ´Â À¯ÀüÀڷμ tyrosine kinase receptor¸¦ codeÇÏ´Â
proto-oncogeneÀÇ À̸§Àº? proto-oncogene c-kit
3. enteric nervous systemÀº Àå¿îµ¿ÀÇ Á¶ÀýÀ» À§ÇØ ¼ö¸¹Àº »óÈ£ ¿¬°áÀ» °¡Áö°í ÀÖ´Ù.
¿©±â¿¡ °ü¿©ÇÏ´Â brain stem³»ÀÇ nucleus 2°¡Áö À̸§?
NTS(nucleus tractus solitarius), DMN(dorsal motor nucleus)
* À̵鿡°Ô¼ inputÀ» ¹Þ´Â afferent neuronÀÇ ½Å°æÀýÀÇ À̸§? prevertebrate ganglia
4. À§Àå°ü ¿îµ¿¼ºÀ» ÀÚ±ØÇϴ ȣ¸£¸ó(ACTING)
Acetylcholine, CCK, 5-hydroxytryptamine, Neurokinin, Gastrin-releasing peptide
5. À§Àå°ü ¿îµ¿¼ºÀ» ¾ïÁ¦Çϴ ȣ¸£¸ó(³ëºêÄ® NP)
NO, VIP, Calcitonin gene-related peptide, Neuropeptide Y, peptide YY, ATP
enteroglucagon
6. À§Àå°ü ¿îµ¿¼º ÀÚ±Ø & ¾ïÁ¦ µÑ´Ù ÀÛ¿ë(NES): neurotensin, enkephalin, somatostatin
7. rapid gastric emptying
dumping syndrome, pancreatic insufficiency, celiac sprue, Zollinger-Ellison syndrome
duodenal ulcer
8. delayed gastric emptying
postvagotomy, DM, viral infecion, reflux esophagitis, brain stem lesions, anorexia
nervosa, tachygastria, systemic sclerosis
9. functional dyspepsiaÀÇ Rome II classification¿¡ µû¸¥ 3 subtypes
: ulcer type, dysmotility type, unspecified type
10. systemic sclerosisȯÀÚ¿¡¼ ³ªÅ¸³ª´Â motility disorder Áõ»ó¿ÏÈ¿¡ µµ¿òÀ» ÁÙ¼ö ÀÖ´Â
¾àÁ¦¿Í ÀÛ¿ë±âÀü?
¾àÁ¦: octreotide *±âÀü: MMCÀÇ phase 3¸¦ stimulation
11. chronic intestinal pseudoobstructionÀ» ÀÏÀ¸Å°´Â ´ëÇ¥Àû ³»ºÐºñÁúȯ 2°¡Áö?
DM, hypothyroidism